Familial Mediterranean Fever Mutation Analysis in Pediatric Patients With Inflammatory Bowel Disease: A Multicenter Study

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dc.contributor.authorUrganci, Nafiye
dc.contributor.authorOzgenc, Funda
dc.contributor.authorKuloglu, Zarife
dc.contributor.authorYuksekkaya, Hasan
dc.contributor.authorSari, Sinan
dc.contributor.authorErkan, Tulay
dc.contributor.authorOnal, Zerrin
dc.date.accessioned2024-02-23T14:41:16Z
dc.date.available2024-02-23T14:41:16Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: the aim of the study was to evaluate familial Mediterranean fever (FMF) mutation analysis in pediatric patients with inflammatory bowel disease (IBD). The relation between MEFV mutations and chronic inflammatory diseases hos been reported previously. Methods: Children with IBD (334 ulcerative colitis (UC), 224 Crohn's disease (CD), 39 indeterminate colitis (IC)) were tested for FMF mutations in this multicenter study. The distribution of mutations according to disease type, histopathological findings, and disease activity indexes was determined. Results: A total of 597 children (mean age: 10.8 +/- 4.6 years, M/F: 1.05) with IBD were included in the study. In this study, 41.9% of the patients had FMF mutations. E148Q was the most common mutation in UC and CD, and M694V in IC (30.5%, 34.5%, 47.1%, respectively). There was a significant difference in terms of endoscopic and histopathological findings according to mutation types (homozygous/heterozygous) in patients with UC (P <.05). There was a statistically significant difference between colonoscopy findings in patients with or without mutations (P=.031, P=.045, respectively). The patients with UC who had mutations had lower Pediatric Ulcerative Colitis Activity Index (PUCAI) scores than the patients without mutations (P=.007). Conclusion: Although FMF mutations are unrelated to CD patients, but observed in UC patients with low PUCAI scores, it was established that mutations do not hove a high impact on inflammatory response and clinical outcome of the disease.en_US
dc.identifier.doi10.5152/tjg.2021.20057
dc.identifier.endpage260en_US
dc.identifier.issn2148-5607
dc.identifier.issue3en_US
dc.identifier.pmid34160354en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage248en_US
dc.identifier.urihttps://doi.org/10.5152/tjg.2021.20057
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16777
dc.identifier.volume32en_US
dc.identifier.wosWOS:000667494100003en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAvesen_US
dc.relation.ispartofTurkish Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectChildrenen_US
dc.subjectFamilial Mediterranean Feveren_US
dc.subjectMefven_US
dc.subjectMutation Analysisen_US
dc.subjectInflammatory Bowel Diseaseen_US
dc.titleFamilial Mediterranean Fever Mutation Analysis in Pediatric Patients With Inflammatory Bowel Disease: A Multicenter Studyen_US
dc.typeArticleen_US

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