The effects of a combination treatment with mesenchymal stem cell and platelet-rich plasma on tendon healing: an experimental study

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dc.contributor.authorUyar, Ilker
dc.contributor.authorAltuntas, Zeynep
dc.contributor.authorFindik, Siddika
dc.contributor.authorYildirim, Mehmet Emin Cem
dc.contributor.authorYarar, Serhat
dc.contributor.authorAktan, Murat
dc.contributor.authorAvci, Alunet
dc.date.accessioned2024-02-23T14:37:25Z
dc.date.available2024-02-23T14:37:25Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground/Aim: The objective of this study was to investigate the effects that the application of mesenchymal stem cells (MSCs) and platelet-rich plasma (PRP) following tendon repair have on the strength and healing of the tendon and also to examine the possible mechanisms of action that take place. Materials and methods: The Achilles tendons of 80 rats were repaired and divided into eight groups. Following the repairs, MSCs obtained from humans were injected into the rat tendons in groups 1 and 2, a combination of MSCs from humans and PRP from rats was injected into the tendons in groups 3 and 4, and PRP from rats was injected into the tendons in groups 5 and 6. These procedures all took place simultaneously. Groups 7 and 8 did not receive any injections following the repairs. The rats were sacrificed at the end of the first and second months following the procedures, and biomechanical and histopathological analyses were performed. Results: Inflammatory cell density increased most significantly in the combined group when compared to the first and second months. The fibroblast density on the tendon repair region was significantly lower in the second-months groups of each intervention compared to their first-month groups (p = 0.001). For the analysis of the maximum tensile breaking force, the behaviors of the groups over time were significant when compared to the control groups (p = 0.0015). Also, the mean maximum breaking force in the combined group was statistically significantly higher at the end of the second month than at the end of the first month (p = 0.0008). Conclusion: The combination therapy increased tendon strength force. This combination therapy can make a positive contribution to the healing of tendons after surgery.en_US
dc.identifier.doi10.3906/sag-2105-145
dc.identifier.endpage247en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.pmid36161600en_US
dc.identifier.scopus2-s2.0-85125358030en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage237en_US
dc.identifier.urihttps://doi.org/10.3906/sag-2105-145
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16099
dc.identifier.volume52en_US
dc.identifier.wosWOS:000761923700027en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectExperimental Studyen_US
dc.subjectMesenchymal Stem Cellen_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.subjectTendon Healingen_US
dc.titleThe effects of a combination treatment with mesenchymal stem cell and platelet-rich plasma on tendon healing: an experimental studyen_US
dc.typeArticleen_US

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