Expression of endocan and vascular endothelial growth factor and their correlation with histopathological prognostic parameters in pheochromocytoma

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dc.contributor.authorKocabas, Muhammet
dc.contributor.authorCan, Mustafa
dc.contributor.authorKarakose, Melia
dc.contributor.authorEsen, Haci Hasan
dc.contributor.authorKulaksizoglu, Mustafa
dc.contributor.authorKarakurt, Feridun
dc.date.accessioned2024-02-23T13:59:44Z
dc.date.available2024-02-23T13:59:44Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjectiveEndocan and vascular endothelial growth factor (VEGF) are markers expressed in various cancer types that are highly vascular, and they have prognostic significance for these cancers. In this study, we aimed to show the expression of endocan and VEGF in pheochromocytoma tumor tissues and to evaluate their correlations with histopathological parameters.Material and methodsThirty-eight patients who had been operated for pheochromocytoma were included in the study. As the control group, 28 subjects whose specimens contained normal adrenal medulla tissue were included. The formalin-fixed paraffin-embedded specimens of pheochromocytoma patients were evaluated for Pheochromocytoma of the Adrenal gland Scaled Score (PASS). Sections were then stained for immunohistochemical analysis. The degree of endocan and VEGF positivity was determined by the proportion of stained cells on a negative to strong scale.ResultsEndocan (p < 0.001) and VEGF (p = 0.004) expressions were found to be significantly higher in the pheochromocytoma group than in the control group. In the pheochromocytoma group, total PASS score (r = 0.714; p < 0.001) and most of the PASS score components were positively correlated with the level of endocan expression. Median Ki-67 index (p = 0.010), total PASS score (p < 0.001), tumor cell spindling (p = 0.048), and nuclear pleomorphism (p = 0.030) were higher in pheochromocytoma with VEGF expression than in those without.ConclusionIf our findings are supported by studies with a larger sample size, we think that endocan has the potential to be used both as a tumor marker and in predicting malignancy potential in patients with pheochromocytoma, and that the detection of VEGF expression in these tumors is also associated with an increase in malignancy potential.en_US
dc.identifier.doi10.1007/s12020-023-03489-2
dc.identifier.endpage645en_US
dc.identifier.issn1355-008X
dc.identifier.issn1559-0100
dc.identifier.issue3en_US
dc.identifier.pmid37596456en_US
dc.identifier.scopus2-s2.0-85168321053en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage638en_US
dc.identifier.urihttps://doi.org/10.1007/s12020-023-03489-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11303
dc.identifier.volume82en_US
dc.identifier.wosWOS:001050549300001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEndocrineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPheochromocytomaen_US
dc.subjectPassen_US
dc.subjectEndocanen_US
dc.subjectVascular Endothelial Growth Factoren_US
dc.subjectImmunohistochemistryen_US
dc.subjectAdrenal Medullaen_US
dc.titleExpression of endocan and vascular endothelial growth factor and their correlation with histopathological prognostic parameters in pheochromocytomaen_US
dc.typeArticleen_US

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