Comparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in experimental animals with peritonitis

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dc.contributor.authorYildirim, Mehmet Aykut
dc.contributor.authorCakir, Murat
dc.contributor.authorFindik, Siddika
dc.contributor.authorKisi, Omer
dc.contributor.authorSenturk, Mustafa
dc.date.accessioned2024-02-23T13:59:58Z
dc.date.available2024-02-23T13:59:58Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIntroduction In spite of advances in surgical techniques, the significance of anastomosis leak continues in colorectal surgery. There is no ideal method in spite of all studies and technical advances in this field. Our aim of this study was to use fibroblast growth factor collagen (FGF-C) and antibiotic collagen (AB-C) to increase the rate of anastomosis healing in experimental animals with peritonitis. Methods This animal experimental study received ethics committee approval. The animals were divided into three groups of seven animals each; the first group was control, the second group was the fibroblast growth factor collagen group, and the third group was the antibiotic collagen group. Under anesthesia, more than 50% of the colonic lumen was opened 4-5 cm distal to the ileocecal junction to create a defect. Twenty-four hours later, primary anastomosis was performed. The second group had the anastomosis line covered with a cover containing FGF-C. The third group had the anastomosis line covered by material containing AB-C. The experiment was concluded on the postoperative 7th day, and the anastomosis burst pressure, tissue hydroxyproline level, and histopathological assessment were performed. Results Though the burst pressure was higher in the experimental groups, it was not statistically significant. In the second and third groups, vascular proliferation and fibroblastic activity appeared to be better than in the control group. Hydroxyproline values were statistically significant in the experimental groups compared to the control group. Conclusion FGF-C and AB-C may have potential utility in anastomosis healing, especially in those susceptible to infection due to anastomosis leak.en_US
dc.identifier.doi10.1007/s12664-020-01145-5
dc.identifier.endpage315en_US
dc.identifier.issn0254-8860
dc.identifier.issn0975-0711
dc.identifier.issue3en_US
dc.identifier.pmid34019242en_US
dc.identifier.scopus2-s2.0-85106058195en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage309en_US
dc.identifier.urihttps://doi.org/10.1007/s12664-020-01145-5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11396
dc.identifier.volume40en_US
dc.identifier.wosWOS:000652936100003en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Indiaen_US
dc.relation.ispartofIndian Journal Of Gastroenterologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnastomosisen_US
dc.subjectCollagenen_US
dc.subjectCollagen With Antibioticen_US
dc.subjectColonen_US
dc.subjectGastrointestinalen_US
dc.subjectPeritonitisen_US
dc.subjectSurgeryen_US
dc.subjectTopicalen_US
dc.subjectWound Healingen_US
dc.titleComparison of the efficacy of growth factor collagen and antibiotic collagen on colon anastomosis in experimental animals with peritonitisen_US
dc.typeArticleen_US

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