The effect of gabapentin and pregabalin on intestinal incision wound healing in rabbits

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dc.contributor.authorKorkmaz, M.
dc.contributor.authorSaritas, T. B.
dc.contributor.authorSevimli, A.
dc.contributor.authorSaritas, Z. K.
dc.contributor.authorElitok, B.
dc.date.accessioned2024-02-23T14:31:28Z
dc.date.available2024-02-23T14:31:28Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractAim: To evaluate the macroscopic and histologic effects of pregabalin (PG) gabapentin (GB) on longitudinal intestinal wound healing in New Zealand rabbits. Materials and Methods: The animals were divided into three groups randomly; the control group (n=6), PG group (n=6) and GB group (n=6). All animals were premedicated with xylazine HCI, 5 mg/kg i.m. and general anaesthesia was performed by ketamine HCI 50 mg/kg i. m injection. A 4 cm incision in the caecum through median laparotomy was achieved under aseptic surgery. Intestinal wound was closed with double-sutured. All animals were received parenteral antibiotic treatment for 5 days. PG and GB groups were treated by PG (30 mg/kg, oral, daily) and GB (30 mg/kg, oral, daily) for 10 days respectively. Control group did not receive any treatment. The animals were euthanized on day 10 and the caecum was examined by laparotomy. Adhesion formation was observed, and tissue samples were taken from suture lines for histologic examination. Cellular infiltration (polymorphonuclear white blood cells and mononuclear cells), accumulation of connective tissue, vascularization and extent of necrosis were evaluated and scored separately for each of mucosal, submucosal, muscular and serosal layers of caecum. Results: Adhesions were more severe in the GB group compared to other groups. No statistically significant differences were detected among the three groups about the wound healing. Conclusion: It was suggested that the use of gabapentinoids had no significant effect on wound healing in patients undergoing gastrointestinal surgery and further studies with treatment periods longer than 10 days are needed.en_US
dc.description.sponsorshipAfyon Kocatepe University, Research Fund (AKU) [13.HIZ.DES.61]en_US
dc.description.sponsorshipThis study was supported by Afyon Kocatepe University, Research Fund (AKU BAPK, 13.HIZ.DES.61).en_US
dc.identifier.doi10.14202/vetworld.2015.279-283
dc.identifier.endpage283en_US
dc.identifier.issn0972-8988
dc.identifier.issn2231-0916
dc.identifier.issue3en_US
dc.identifier.pmid27047085en_US
dc.identifier.scopus2-s2.0-84924605401en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage279en_US
dc.identifier.urihttps://doi.org/10.14202/vetworld.2015.279-283
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15203
dc.identifier.volume8en_US
dc.identifier.wosWOS:000217580900005en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherVeterinary Worlden_US
dc.relation.ispartofVeterinary Worlden_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectGabapentinen_US
dc.subjectIntestinal Incisional Wounden_US
dc.subjectPregabalinen_US
dc.subjectRabbiten_US
dc.titleThe effect of gabapentin and pregabalin on intestinal incision wound healing in rabbitsen_US
dc.typeArticleen_US

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