Genetic variations in interleukin 6 rs1800795 polymorphism and the association with susceptibility to Hashimoto's thyroiditis

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dc.contributor.authorErdogan, M.
dc.contributor.authorKulaksizoglu, M.
dc.contributor.authorGanidagli, S.
dc.contributor.authorBerdeli, A.
dc.date.accessioned2024-02-23T14:13:16Z
dc.date.available2024-02-23T14:13:16Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractHashimoto's disease is a polygenic disorder with complex etiopathogenesis. The imbalance between pro- and anti-inflammatory cytokines may play a role in the etiology. We aimed to evaluate the relation between 174 promoter region of the interleukin 6 rs1800795 gene polymorphism in patients with Hashimoto's thyroiditis (HT). We studied 110 HT patients and 110 healthy controls. The evaluation of genotype for interleukin 6 rs1800795 gene polymorphism were performed by using PCR-RFLP method. The genotype of IL6 distribution did differ between the control group (CC 17.3%, GC 78.2%, GG 4.5%) and the HT patients (CC 29.1%, GC 46.4%, GG 24.5%) (p < 0.001). The frequency of the polymorphic G allele was similar for the group with HT patients as the control group with 47.7% and 43.6%, respectively (p > 0.05). Our results indicate that interleukin 6 rs1800795 polymorphism may be associated with susceptibility to HT in Turkish Patients. It is necessary to confirm the results and determine the underlying pathogenic mechanisms in further studies. (C) 2016 Elsevier B.V. All rights reserved.en_US
dc.identifier.doi10.1016/j.mgene.2016.12.010
dc.identifier.endpage3en_US
dc.identifier.issn2214-5400
dc.identifier.scopus2-s2.0-85008957418en_US
dc.identifier.startpage1en_US
dc.identifier.urihttps://doi.org/10.1016/j.mgene.2016.12.010
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12350
dc.identifier.volume12en_US
dc.identifier.wosWOS:000418337000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofMeta Geneen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIl-6en_US
dc.subjectGene Polymorphismen_US
dc.subjectHashimoto's Thyroiditisen_US
dc.titleGenetic variations in interleukin 6 rs1800795 polymorphism and the association with susceptibility to Hashimoto's thyroiditisen_US
dc.typeArticleen_US

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