The relationship between insulin resistance and leptin, interleukin-6, hs-CRP and fibrinogen in obesity

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dc.contributor.authorKocak, Ahmet
dc.contributor.authorKutlu, Ruhusen
dc.contributor.authorCivi, Selma
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T14:41:37Z
dc.date.available2024-02-23T14:41:37Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObesity is still an actual subject because of its rapidly increasing prevalence. Although it is not a serious disease by itself, obesity plays an important role in the development of diabetes mellitus and cardiovasculer diseases. In this study, we aimed to investigate the relationship between insulin resistance and interleukin-6, leptin, hs-CRP and fibrinogen in obese and non-obese individuals. Methods: This study, which is an analytical study in the case-control type, was conducted on 329 adult individuals. Heights, weights, body mass indexes (BMI), waist circumferences, blood pressures, fasting blood glucose (FBG), total cholesterol, triglyceride, LDL-c, HDL-c, hs-CRP, leptin, IL-6, fibrinogen, and insulin levels were measured. Results: Of all the participants, 204 (62.0%) were female, 125 (38.0%) were male; 71 of them were of (21.5%) normal weight, 89 (27.1%) were overweight and 169 were (51.4%) obese. There was a significant correlation between low educational level and obesity (p<0.001). The married participants exhibited higher rates of being overweight and obese than other groups (p<0.001). There was a significant relationship between FBG, TG, HDL-c levels in male/female gender and BMI, statistically (p<0.05). In our study, a significant correlation was found between insulin, insulin resistance, hs-CRP, fibrinogen, leptin levels, low HDL-c levels and obesity (p<0.05). No statistically significant relationship was found between IL-6 and obesity (p>0.05). As a result of the multiple regression analysis, HOMA-IR, leptin ve hs-CRP levels was found as the effective basic factors on obesity. On the other hand, there was a significant relationship between high blood pressure and obesity (p<0.001). Conclusion: In our study, high fasting blood glucose, TG, insulin, insulin resistance, hs-CRP, fibrinogen, leptin and low HDL-c levels were found to be correlated with obesity. This correlation leads to many diseases, notably diabetes mellitus and cardio-vascular diseases.en_US
dc.identifier.doi10.5505/tjb.2014.20981
dc.identifier.endpage382en_US
dc.identifier.issn0250-4685
dc.identifier.issn1303-829X
dc.identifier.issue3en_US
dc.identifier.scopus2-s2.0-84912030890en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage373en_US
dc.identifier.urihttps://doi.org/10.5505/tjb.2014.20981
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16933
dc.identifier.volume39en_US
dc.identifier.wosWOS:000346148200018en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isotren_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofTurkish Journal Of Biochemistry-Turk Biyokimya Dergisien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectFibrinogenen_US
dc.subjectHs-Crpen_US
dc.subjectIl-6en_US
dc.subjectInsulin Resistanceen_US
dc.subjectLeptinen_US
dc.subjectObesityen_US
dc.titleThe relationship between insulin resistance and leptin, interleukin-6, hs-CRP and fibrinogen in obesityen_US
dc.typeArticleen_US

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