Effects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetes

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dc.contributor.authorSeflek, H. N.
dc.contributor.authorKalkan, S.
dc.contributor.authorCuce, G.
dc.contributor.authorKilinc, I.
dc.contributor.authorSozen, M. E.
dc.date.accessioned2024-02-23T14:20:28Z
dc.date.available2024-02-23T14:20:28Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractWe investigated the effects of Nigella sativa oil on ovary volume, nuclear factor-kappaB (NF-kappa B), X-linked inhibitor of apoptosis protein (XIAP) expression, and serum malondialdehyde (MDA), superoxide dismutase (SOD), total antioxidant status (TAS) and total oxidant status (TOS) levels in diabetic rats. We divided 21 adult female rats into three groups: controls, diabetics and diabetics + N. sativa oil. The diabetics + N. sativa oil group was given 0.2mg/kg/day N. sativa oil 6days/week for 4weeks. NF-kappa B and XIAP expression was assessed in ovarian sections using immunohistochemistry. The right and left ovary volumes were calculated using stereology. We also measured serum MDA, SOD, TAS and TOS levels. We found that N. sativa oil reduced hyperglycemia, but not to control levels. N. sativa oil also exhibited antioxidant properties as demonstrated by reduced serum TOS and MDA levels, and increased SOD and TAS levels compared to controls. We found no significant difference in total ovarian volume, XIAP or NF-kappa B expression among the groups, which may be due to the short study period. Our findings suggest that N. sativa oil may be useful for reducing blood glucose levels and elevated oxidant activity in diabetic patients.en_US
dc.description.sponsorshipScientific Research Projects Coordination Office of Necmettin Erbakan University, Konya, Turkey [141318002]en_US
dc.description.sponsorshipFunding for this research was provided by Scientific Research Projects Coordination Office of Necmettin Erbakan University, Konya, Turkey (project 141318002).en_US
dc.identifier.doi10.1080/10520295.2019.1566571
dc.identifier.endpage333en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue5en_US
dc.identifier.pmid30821520en_US
dc.identifier.scopus2-s2.0-85062449292en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage325en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2019.1566571
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13162
dc.identifier.volume94en_US
dc.identifier.wosWOS:000482264200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidantsen_US
dc.subjectApoptosisen_US
dc.subjectDiabetesen_US
dc.subjectNigella Sativa Oilen_US
dc.subjectOvaryen_US
dc.subjectOxidanten_US
dc.subjectStereologyen_US
dc.titleEffects of Nigella sativa oil on ovarian volume, oxidant systems, XIAP and NF-kB expression in an experimental model of diabetesen_US
dc.typeArticleen_US

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