Mental status and physical activity in patients with homozygous familial hypercholesterolemia: A subgroup analysis of a nationwide survey (A-HIT1 registry)

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dc.contributor.authorTuncel, Ozlem Kuman
dc.contributor.authorKayikcioglu, Meral
dc.contributor.authorPirildar, Sebnem
dc.contributor.authorYilmaz, Mehmet
dc.contributor.authorKaynar, Leylagul
dc.contributor.authorAktan, Melih
dc.contributor.authorDurmus, Rana Berru
dc.date.accessioned2024-02-23T14:12:31Z
dc.date.available2024-02-23T14:12:31Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: Homozygous familial hypercholesterolemia (HoFH) is a rare, life-threatening disease due to high serum low-density lipoprotein (LDL) cholesterol levels. LDL cholesterol-lowering interventions are fundamental for patients with HoFH. OBJECTIVE: It was aimed to investigate the association between the mental status of patients with HoFH and healthy lifestyle behaviors. METHODS: This subgroup analysis of the A-HIT1 population included the data of patients aged >= 18 years with a clinical diagnosis of HoFH undergoing therapeutic LDL apheresis. Besides the demographic and clinical characteristics of patients, healthy lifestyle behaviors were assessed, and psychiatric symptoms were screened by Symptom Check List (SCL-90-R). RESULTS: The highest percentage for pathology was observed in dimensions of obsessive-compulsive, somatization, interpersonal sensitivity, and depression in SCL-90-R. Patients with any cardiovascular condition have more psychiatric symptoms in different fields of SCL-90-R. The outcomes of the correlative analysis indicated that lower the age of the first coronary event better the psychiatric status, probably denoting a better adaptation to disease and its treatment. Among 68 patients, 36 patients were not exercising regularly. Patients with regular physical activity had significantly lower scores in most dimensions of SCL-90-R and there was no association between regular physical activity and other investigated variables. The strongest predictor of regular exercising was global severity index of SCL-90-R. CONCLUSION: In the HoFH population, there was a high prevalence of mental disturbances. Better psychiatric status was associated with regular exercising. Therefore, assessing the mental status of patients with HoFH and referring patients in need, to a psychiatrist, may improve the outcome of patients. (C) 2020 National Lipid Association. All rights reserved.en_US
dc.identifier.doi10.1016/j.jacl.2020.04.006
dc.identifier.endpage+en_US
dc.identifier.issn1933-2874
dc.identifier.issn1876-4789
dc.identifier.issue3en_US
dc.identifier.pmid32423761en_US
dc.identifier.scopus2-s2.0-85085098192en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage361en_US
dc.identifier.urihttps://doi.org/10.1016/j.jacl.2020.04.006
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12089
dc.identifier.volume14en_US
dc.identifier.wosWOS:000540548500013en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevier Science Incen_US
dc.relation.ispartofJournal Of Clinical Lipidologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHomozygous Familial Hypercholesterolemiaen_US
dc.subjectGlobal Severity Indexen_US
dc.subjectHofhen_US
dc.subjectLdlen_US
dc.subjectLdl Apheresisen_US
dc.subjectMental Stateen_US
dc.subjectPhysical Activityen_US
dc.subjectPsychiatryen_US
dc.subjectPsychopathologyen_US
dc.subjectSymptom Check Listen_US
dc.titleMental status and physical activity in patients with homozygous familial hypercholesterolemia: A subgroup analysis of a nationwide survey (A-HIT1 registry)en_US
dc.typeArticleen_US

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