Reprograming cancer cells by a BODIPY G-quadruplex stabiliser

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dc.contributor.authorBaser, Aminesena
dc.contributor.authorBasar, Beyza
dc.contributor.authorDogan, Hanim Beyza
dc.contributor.authorSener, Gulnur
dc.contributor.authorOzsamur, Nezahat Gokce
dc.contributor.authorCelik, Fatma Secer
dc.contributor.authorAltves, Safaa
dc.date.accessioned2024-02-23T14:16:47Z
dc.date.available2024-02-23T14:16:47Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractA cationic BODIPY-based G-quadruplex-selective stabiliser is developed and shown to decrease cancer cell migration-invasion up to 90%. The expression of critical genes (HIF1 alpha, VIM, CDH1) related to metastasis is modulated. The stabiliser reprograms hypoxia-adaptive metabolism and an 1.82-fold increase in O2 consumption, enabling back-to-normal switching of energy metabolism, is observed. Stabilisers with a strong G-quadruplex affinity (0.38 mu M Kd) significantly contribute to small molecule anti-cancer approaches. A BODIPY-based G-quadruplex-selective stabiliser is shown to silence regulator genes, reduce cell migration and invasion, and switch off the hypoxia-adaptive metabolism.en_US
dc.description.sponsorshipTUBITAK [120C125, TUBITAK 2209-A]en_US
dc.description.sponsorshipThis project is supported by TUBITAK Grant No: 120C125 and TUBITAK 2209-A.en_US
dc.identifier.doi10.1039/d3cc03453d
dc.identifier.issn1359-7345
dc.identifier.issn1364-548X
dc.identifier.pmid37779498en_US
dc.identifier.scopus2-s2.0-85173710783en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1039/d3cc03453d
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12802
dc.identifier.wosWOS:001076734000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherRoyal Soc Chemistryen_US
dc.relation.ispartofChemical Communicationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleReprograming cancer cells by a BODIPY G-quadruplex stabiliseren_US
dc.typeArticleen_US

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