Comparison of the Effect of Platelet-Rich Plasma and Simvastatin on Healing of Critical-Size Calvarial Bone Defects

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dc.contributor.authorSeyhan, Nevra
dc.contributor.authorKeskin, Suat
dc.contributor.authorAktan, Murat
dc.contributor.authorAvunduk, Mustafa Cihad
dc.contributor.authorSengelen, Meltem
dc.contributor.authorSavaci, Nedim
dc.date.accessioned2024-02-23T14:23:29Z
dc.date.available2024-02-23T14:23:29Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractObjective: In previous studies, it has been shown that both simvastatin (chlolesterollowering drug) and platelet-rich plasma (PRP) were capable of promoting bone formation. The aim of this study was to compare the effects of PRP and simvastatin on healing of critical-size bone defects. Methods: A total of 33 rats (3 for PRP preparation) were used in the experiment. Critical-size defect 8-mm diameter was created in 30 rats' calvarium. Rats were divided into 3 groups. Each group contained 10 animals. In Group A the defect was filled with phosphate-buffered saline only, in Group B with 0.5 mL PRP, and in Group C with 0.1 mg simvastatin. The defects were evaluated by radiographic analysis at 8th and 16th weeks. The animals were sacrificed 16 weeks after the surgery. Histological examination was performed to assess the new bone-forming area. Vessels, fibroblasts, osteoblasts, and osteoclasts were marked in 524749.1-mu m(2) area and counted with using Clemex Vision Lite 3.5 Image Analysis program. The results were statistically analyzed.en_US
dc.identifier.doi10.1097/SCS.0000000000002728
dc.identifier.endpage1370en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue5en_US
dc.identifier.pmid27300463en_US
dc.identifier.scopus2-s2.0-84974687070en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage1367en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000002728
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13569
dc.identifier.volume27en_US
dc.identifier.wosWOS:000379793500096en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCritical-Size Bone Defecten_US
dc.subjectPlatelet-Rich Plasmaen_US
dc.subjectSimvastatinen_US
dc.titleComparison of the Effect of Platelet-Rich Plasma and Simvastatin on Healing of Critical-Size Calvarial Bone Defectsen_US
dc.typeArticleen_US

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