Comparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal model

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dc.contributor.authorKuru, Murat
dc.contributor.authorAltinok, Tamer
dc.contributor.authorMetin, Bayram
dc.contributor.authorEsen, Haci Hasan
dc.date.accessioned2024-02-23T14:32:05Z
dc.date.available2024-02-23T14:32:05Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjectives: To investigate the positive effects of intraperitoneal administration of alpha-lipolic acid (ALA) and dexpanthenol (DXP) on wound healing after tracheal surgery in rats. Methods: The study was carried out at Necmettin Erbakan University, Konya, Turkey, from January 2014-2019. A total of 30 healthy and adult Sprague-Dawley type female rats were included in the study. For the experiment, rats were randomly divided into 3 groups: ALA group (n=10), DXP group (n=10), and control group (n=10). After trachea surgery, 100 mg/kg/day ALA was given to group ALA and 100 mg/kg/day intraperitoneal DXP to group DXP for 15 days, and the rats were sacrificed on the 21st day. The excised tracheal sections were evaluated and graded for inflammatory cell infiltration, angiogenesis, fibroblast proliferation, collagen deposition, and epithelial regeneration to evaluate wound healing. Results: Inflammation was found to be less in both the ALA and DXP groups. With the Mann-Whitney test, it was determined that inflammation was less in the ALA group than in the DXP group (C-D [p=0.097] and C-A [p=0.024]). On the other hand, no statistically significant difference was found in epithelial regeneration (p=0.574; >0.05), angiogenesis (p=0.174; >0.05), fibroblast proliferation, and collagen deposition (p=0.102; >0.05). Conclusion: Alpha-lipolic acid injected intravenously after tracheal reconstruction in patients can prevent restenosis by reducing inflammation without adversely affecting wound healingen_US
dc.identifier.doi10.15537/smj.2023.44.9.20230243
dc.identifier.endpage869en_US
dc.identifier.issn0379-5284
dc.identifier.issn1658-3175
dc.identifier.issue9en_US
dc.identifier.pmid37717974en_US
dc.identifier.scopus2-s2.0-85171490774en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage864en_US
dc.identifier.urihttps://doi.org/10.15537/smj.2023.44.9.20230243
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15480
dc.identifier.volume44en_US
dc.identifier.wosWOS:001083394300004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSaudi Med Jen_US
dc.relation.ispartofSaudi Medical Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectTracheaen_US
dc.subjectAlpha-Lipoic Aciden_US
dc.subjectDexpanthenolen_US
dc.subjectInflammationen_US
dc.subjectStenosisen_US
dc.titleComparison of the effects of alpha lipoic acid and dexpanthenol in an experimental tracheal reconstruction animal modelen_US
dc.typeArticleen_US

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