Clinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Survey

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dc.contributor.authorEren, Erdal
dc.contributor.authorErgur, Ayca Torel
dc.contributor.authorIsguven, Sukriye Pinar
dc.contributor.authorBitkin, Eda Celebi
dc.contributor.authorBerberoglu, Merih
dc.contributor.authorSiklar, Zeynep
dc.contributor.authorBas, Firdevs
dc.date.accessioned2024-02-23T14:38:10Z
dc.date.available2024-02-23T14:38:10Z
dc.date.issued2019
dc.departmentNEÜen_US
dc.description.abstractObjective: We aimed to report the characteristics at admission, diagnosis, treatment, and follow-up of cases of pediatric hyperprolactinemia in a large multicenter study. Methods: We reviewed the records of 233 hyperprolactinemic patients, under 18 years of age, who were followed by different centers. The patients were divided as having microadenomas, macroadenomas, drug-induced hyperprolactinemia and idiopathic hyperprolactinemia. Complaints of the patients, their mode of treatment (medication and/or surgery) and outcomes were evaluated in detail. Results: The mean age of the patients with hyperprolactinemia was 14.5 years, and 88.4% were females. In terms of etiology, microadenomas were observed in 32.6 %, macroadenomas in 27 %, idiopathic hyperprolactinemia in 22.7% and drug-induced hyperprolactinemia in 6.4 %. Other causes of hyperprolactinemia were defined in 11.3%. Common complaints in females (n = 206) were sorted into menstrual irregularities, headaches, galactorrhea, primary or secondary amenorrhea and weight gain, whereas headache, gynecomastia, short stature and blurred vision were common in males (n = 27). Median prolactin levels were 93.15 ng/mL, 241.8 ng/ml, 74.5 ng/mL, 93.2 ng/mL, and 69 ng/mL for microadenomas, macroadenomas, idiopathic hyperprolactinemia, drug-induced hyperprolactinemia, and other causes of hyperprolactinemia, respectively. Of 172 patients with hyperprolactinemia, 77.3 % were treated with cabergoline and 13.4 % with bromocriptine. 20.1 % of the patients with pituitary adenomas underwent pituitary surgery. Conclusion: We present the largest cohort of children and adolescents with hyperprolactinemia in the literature to date. Hyperprolactinemia is more common in females and cabergoline is highly effective and practical to use in adolescents, due to its biweekly dosing. Indications for surgery in pediatric cases need to be revised.en_US
dc.description.sponsorshipTurkish Pediatric Endocrinology and Diabetes Society [2015-1136]; National Pediatric Endocrinology Societyen_US
dc.description.sponsorshipThis work was supported by a grant from the Turkish Pediatric Endocrinology and Diabetes Society (2015-1136). The authors would like to thank the National Pediatric Endocrinology Society for financial and technical support for the paper.en_US
dc.identifier.doi10.4274/jcrpe.galenos.2018.2018.0206
dc.identifier.endpage156en_US
dc.identifier.issn1308-5727
dc.identifier.issn1308-5735
dc.identifier.issue2en_US
dc.identifier.pmid30396878en_US
dc.identifier.scopus2-s2.0-85067316369en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage149en_US
dc.identifier.urihttps://doi.org/10.4274/jcrpe.galenos.2018.2018.0206
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16395
dc.identifier.volume11en_US
dc.identifier.wosWOS:000469271100006en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGalenos Yayinciliken_US
dc.relation.ispartofJournal Of Clinical Research In Pediatric Endocrinologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPituitaryen_US
dc.subjectProlactinen_US
dc.subjectChildrenen_US
dc.subjectMicroadenomasen_US
dc.subjectMacroadenomasen_US
dc.subjectCabergolineen_US
dc.subjectSurgeryen_US
dc.titleClinical and Laboratory Characteristics of Hyperprolactinemia in Children and Adolescents: National Surveyen_US
dc.typeArticleen_US

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