Treatment of Acute Vocal Fold Injury With Platelet-Rich Plasma

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dc.contributor.authorCobden, Serap Bulut
dc.contributor.authorOzturk, Kayhan
dc.contributor.authorDuman, Selcuk
dc.contributor.authorEsen, Hasan
dc.contributor.authorAktan, Tahsin Murad
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorElsurer, Cagdas
dc.date.accessioned2024-02-23T14:13:04Z
dc.date.available2024-02-23T14:13:04Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.descriptionFall Voice Conference -- OCT 23-25, 2014 -- San Antonio, TXen_US
dc.description.abstractObjectives. Platelet-rich plasma (PRP) is a reliable and has low side-effect profile and has beneficial effects on wound healing. Its investigatory effects on wound-healing process were shown on various tissues. The aim of the present study was to evaluate effectiveness of PRP application on scar tissue of acute vocal fold injury. Materials andmethods. Twenty-fourWistar rats were used in the study. The entire layer of the lamina propria down to the thyroarytenoid muscle of 10 subjects was unilaterally injured by with a microscissor. Gelfoam-absorbed PRP was applied on the injured area for 10 minutes. Control group consisted of rats unilaterally injured using a microscissor, and gelfoam with normal saline was applied on the injured area. Following sacrifice, the larynxes were carefully dissected and removed for histopathologic examination. After excised larynx experiments, serial sections were prepared from vocal fold. Hematoxylin eosin and immunohistochemical staining were done for epithelial growth factor receptor (EGFR), fibroblast growth factor receptor (FGFR1), and vascular endothelial growth factor (VEGF) staining for histopathologic examinations. Results. There was not a significant difference between the two groups for lymphocyte. Although collagen and VEGF were higher in the study group, there was not a significant difference between the groups (P > 0.05). There was a significant difference between control and study groups for EGFR and FGFR1(P < 0.05). Conclusions. PRP has beneficial effects on wound healing. PRP accelerates epithelization of injured rat vocal folds by inducing EGFR secretion. PRP is an autogenous, reliable, low side-effect profile, easily harvested material. PRP may be useful to prevent scar formation.en_US
dc.identifier.doi10.1016/j.jvoice.2015.07.012
dc.identifier.endpage735en_US
dc.identifier.issn0892-1997
dc.identifier.issn1873-4588
dc.identifier.issue6en_US
dc.identifier.pmid26292799en_US
dc.identifier.scopus2-s2.0-84939159830en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage731en_US
dc.identifier.urihttps://doi.org/10.1016/j.jvoice.2015.07.012
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12292
dc.identifier.volume30en_US
dc.identifier.wosWOS:000392619200016en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherMosby-Elsevieren_US
dc.relation.ispartofJournal Of Voiceen_US
dc.relation.publicationcategoryKonferans Öğesi - Uluslararası - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEgfren_US
dc.subjectFgfr1en_US
dc.subjectInjuryen_US
dc.subjectPrpen_US
dc.subjectScaren_US
dc.subjectVegfen_US
dc.subjectVocal Folden_US
dc.titleTreatment of Acute Vocal Fold Injury With Platelet-Rich Plasmaen_US
dc.typeConference Objecten_US

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