Diagnostic and Prognostic Significance of Neutrophil Gelatinase-Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndrome

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dc.contributor.authorOzer, Muhammet Rasit
dc.contributor.authorErgin, Mehmet
dc.contributor.authorKilinc, Ibrahim
dc.contributor.authorDundar, Zerrin Defne
dc.contributor.authorOzer, Nejla
dc.contributor.authorOnal, Mehmet Akif
dc.contributor.authorGirisgin, Abdullah Sadik
dc.date.accessioned2024-02-23T14:41:03Z
dc.date.available2024-02-23T14:41:03Z
dc.date.issued2017
dc.departmentNEÜen_US
dc.description.abstractAim: The aim was to evaluate the levels of serum pentraxin-3 (PTX-3) and neutrophil gelatinase-associated lipocalin (NGAL) and the efficiency of making a diagnosis and to estimate the prognosis in patients with chest pain. Materials and Methods: The study was conducted in the Necmettin Erbakan University Meram Medicine School Emergency Department. Patients who had chest pain and met the inclusion criteria were accepted. They were divided into the following groups: acute coronary syndrome (ACS), a diagnosis other than ACS (non-ACS), and control. The patients in theACS and non-ACS groups were divided into five sub-group - groups: ST Elevated Myocardial Infarction (STEMI) Non-ST Elevated Myocardial Infarction (NSTEMI), Unstable Angina Pectoris (USAP), stable angina, and pulmonary embolus. For all patients, serum PTX-3, serum NGAL, troponin I, and creatine kinase-MB fraction (CK-MB) levels were measured. Results: There were 199 patients in the ACS and non-ACS groups and 30 patientsin the control group. There was no significant difference among the study groups in terms of age and PTX-3 and NGAL levels. When comparing survival and non-survival in terms of in-hospital death, CK-MB and troponin I levels were significantly higher in the ACS and non-ACS groups than in the control groups, whereas there was no significant difference in terms of PTX-3 and NGAL levels. Conclusion: The results of our study demonstrated that PTX-3 and NGAL are not effective biomarkers in the differential diagnosis and the determination of in-hospital mortality in ACS. However, the limitations of the study should be considered. The results confirmed that CK-MB and Troponin I can be safely used in the differential diagnosis and the prediction of mortality.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Project (BAP) [14158005]en_US
dc.description.sponsorshipThis study was supported by Necmettin Erbakan University Scientific Research Project (BAP) (project no: 14158005).en_US
dc.identifier.doi10.5152/eajem.2017.28290
dc.identifier.endpage18en_US
dc.identifier.issn2149-5807
dc.identifier.issn2149-6048
dc.identifier.issue1en_US
dc.identifier.startpage12en_US
dc.identifier.urihttps://doi.org/10.5152/eajem.2017.28290
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16689
dc.identifier.volume16en_US
dc.identifier.wosWOS:000398905900004en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isoenen_US
dc.publisherGalenos Publ Houseen_US
dc.relation.ispartofEurasian Journal Of Emergency Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAcute Coronary Syndromeen_US
dc.subjectBiomarkeren_US
dc.subjectNeutrophil Gelatinase-Associated Lipocalinen_US
dc.subjectPentraxin-3en_US
dc.titleDiagnostic and Prognostic Significance of Neutrophil Gelatinase-Associated Lipocalin and Pentraxin-3 in Acute Coronary Syndromeen_US
dc.typeArticleen_US

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