General properties of autoimmune thyroid diseases and associated morbidities

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dc.contributor.authorIbili, Aysel Burcu Palandokenlier
dc.contributor.authorEklioglu, Beray Selver
dc.contributor.authorAtabek, Mehmet Emre
dc.date.accessioned2024-02-23T14:29:51Z
dc.date.available2024-02-23T14:29:51Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractBackground: Autoimmune thyroid diseases (ATDs) can be classified into two basic diseases: Graves' disease (GD) and Hashimoto's thyroiditis (HT). Here, we review the effectiveness of laboratory and imaging methods used for the early diagnosis of ATD and draw attention to methods that may improve screening. Methods: Retrospective data of 142 patients diagnosed with ATD between January 2010 and December 2015 at our paediatric endocrinology clinic were used. Sociodemographic characteristics, clinical findings, treatments and follow-up data of patients were statistically evaluated. Results: Of the ATD cases, 81% (n = 115) were female. The median age was 12.5 +/- 3.5 (range 1-17) years and 91% (n = 129) of patients were in puberty. There was a significant positive correlation between the height (standard deviation score) and follow-up time for patients with HT (r = 0.156, p < 0.01). Thyroglobulin antibody (TgAb) positivity was found in 75% (45/60) of females with a positive maternal ATD history ( p = 0.045). Thyroid-stimulating hormone (TSH), free triiodothyronine (fT3), free thyroxine (fT4) values were significantly altered during the treatment follow-up period in female patients with GD and HT, while only fT4 values were found to be significantly altered in boys with HT. Conclusion: Although GD and HT have similar mechanisms, they differ in terms of treatment duration and remission and relapse frequencies. Ultrasonography (USG) screening is a non-invasive procedure that is suitable for all patients with ATD. Based on our results, TgAb could be useful in the screening of girls with a history of maternal ATD.en_US
dc.identifier.doi10.1515/jpem-2019-0331
dc.identifier.endpage515en_US
dc.identifier.issn0334-018X
dc.identifier.issn2191-0251
dc.identifier.issue4en_US
dc.identifier.pmid32126013en_US
dc.identifier.scopus2-s2.0-85082031315en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage509en_US
dc.identifier.urihttps://doi.org/10.1515/jpem-2019-0331
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14886
dc.identifier.volume33en_US
dc.identifier.wosWOS:000524402800008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWalter De Gruyter Gmbhen_US
dc.relation.ispartofJournal Of Pediatric Endocrinology & Metabolismen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAutoimmune Thyroiden_US
dc.subjectGravesen_US
dc.subjectHashimotoen_US
dc.titleGeneral properties of autoimmune thyroid diseases and associated morbiditiesen_US
dc.typeArticleen_US

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