Simply patterned reduced graphene oxide as an effective biosensor platform for glucose determination

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dc.contributor.authorSoganci, Kubra
dc.contributor.authorBingol, Haluk
dc.contributor.authorZor, Erhan
dc.date.accessioned2024-02-23T14:12:47Z
dc.date.available2024-02-23T14:12:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractDiabetes is one of the most serious diseases affecting human health worldwide. Maintaining a certain level of glucose concentration is key for diabetes. Driven by the increasing demand for simply prepared, low-cost, and flexible sensing systems, we developed reduced graphene oxide (rGO) patterns-based amperometric sensor for glucose determination. The rGO patterns were produced by stamping of patterned graphene oxide (GO) on polyethylene terephthalate (PET) substrates using filtration/wax-printing method and then reducing to rGO for providing conductivity. The prepared graphene-based patterns were modified by glucose oxidase (GOx) and used as an excellent working electrode for electrochemical enzymatic determination of glucose, as a model sensing. The proposed biosensor exhibited an ultra-fast response time of 0.37 s and the sensitivity of 11.2 ?A mM?1 cm?2 with a linear concentration range of 1.0?25.0 mM and a satisfactory low detection limit of 0.32 mM.Besides, it showed good reproducibility, stability, selectivity, and anti-interference ability in glucose determination. The results present that the fabricated platform can be employed for the determination of glucose in human serum, which indicates its promising applicability in the real sample analysis. The effective proof-of-concept for the determination of glucose can be applied to different (bio)sensing systems to miniaturize of detection instrument.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Projects Coordination Unit [191210001]en_US
dc.description.sponsorshipA part of this study was supported by Necmettin Erbakan University Scientific Research Projects Coordination Unit (project no: 191210001).en_US
dc.identifier.doi10.1016/j.jelechem.2020.114801
dc.identifier.issn1572-6657
dc.identifier.issn1873-2569
dc.identifier.scopus2-s2.0-85096165037en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.jelechem.2020.114801
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12177
dc.identifier.volume880en_US
dc.identifier.wosWOS:000639615200003en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherElsevier Science Saen_US
dc.relation.ispartofJournal Of Electroanalytical Chemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGraphene Oxideen_US
dc.subjectConductive Patternen_US
dc.subjectPatterningen_US
dc.subjectNanotechnologyen_US
dc.subjectChronoamperometryen_US
dc.subjectGlucose Sensoren_US
dc.titleSimply patterned reduced graphene oxide as an effective biosensor platform for glucose determinationen_US
dc.typeArticleen_US

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