Clearance of Intravitreal Daptomycin in Uveitis-Induced Rabbit Model

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dc.contributor.authorOzcimen, Muammer
dc.contributor.authorSakarya, Yasar
dc.contributor.authorOzcimen, Serap
dc.contributor.authorSakarya, Rabia
dc.contributor.authorGoktas, Sertan
dc.contributor.authorIyisoy, Sinan
dc.contributor.authorAlpfidan, Ismail
dc.date.accessioned2024-02-23T14:34:36Z
dc.date.available2024-02-23T14:34:36Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractPurpose: To investigate the elimination rate of daptomycin after intravitreal injection in uveitis-induced rabbits. Materials and methods: Intravitreal injection of the single dose of 200 mu g/0.05mL daptomycin was administered to rabbits starting 24 h after induction of uveitis by an intravitreal endotoxin injection. Aqueous humor and vitreous humor samples of eight eyes per time point were collected at selected time intervals (1, 3, 6, 24, 48, 72 and 96 h), and the in vitreous half-life was calculated. Daptomycin concentrations in vitreous and aqueous humor were assayed with high-performance liquid chromatography. Results: The vitreous concentration was noted to decline slowly with time. The mean vitreous concentration was 23.25 +/- 10.99 mu g/mL and 11.10 +/- 3.33 mu g/mL at 96 h in inflamed and normal eyes, respectively. The vitreous daptomycin concentration showed an exponential decay with a half-life of 25.67 h in normal eyes and 34.6 h in inflamed eyes. The aqueous levels of daptomycin in normal eyes were low but remained significantly higher than those of inflamed eyes. Conclusions: Given that the injected dose corresponds to several times the minimum inhibitory concentrations of organisms most involved in endophthalmitis, and that therapeutic levels are present up to 96 h after injection, intravitreal daptomycin should be considered for the treatment of endophthalmitis caused by Gram-positive bacteria.en_US
dc.description.sponsorshipKonya Training and Research Hospital, Konya, Turkey [KTRH-28]en_US
dc.description.sponsorshipThis work was supported by grants from Konya Training and Research Hospital (KTRH-28), Konya, Turkey.en_US
dc.identifier.doi10.3109/02713683.2014.941072
dc.identifier.endpage603en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue6en_US
dc.identifier.pmid25110947en_US
dc.identifier.scopus2-s2.0-84928791014en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage598en_US
dc.identifier.urihttps://doi.org/10.3109/02713683.2014.941072
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15653
dc.identifier.volume40en_US
dc.identifier.wosWOS:000353579000007en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntibiotic Resistanceen_US
dc.subjectClearanceen_US
dc.subjectDaptomycinen_US
dc.subjectEndophthalmitisen_US
dc.subjectLiquid Chromatographyen_US
dc.titleClearance of Intravitreal Daptomycin in Uveitis-Induced Rabbit Modelen_US
dc.typeArticleen_US

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