Incidence of congenital heart disease with consanguinity: 10 years of experience in a single-center
Küçük Resim Yok
Tarih
2023
Yazarlar
Dergi Başlığı
Dergi ISSN
Cilt Başlığı
Yayıncı
Bayrakol Medical Publisher
Erişim Hakkı
info:eu-repo/semantics/openAccess
Özet
Aim: Congenital heart diseases (CHD) are inborn structural and functional anomalies of the heart and its great vessels. It is considered to have a multifactorial origin. This study aims to determine the frequency and types of CHD between siblings in Central Anatolia and investigate consanguineous marriages' contribution to this undesirable incidence. Material and Methods: The study included 1916 children admitted to the pediatric cardiology outpatient clinic between 2009-2019. Congenital heart diseases were grouped as uncomplex CHD, complex CHD, heart muscle diseases and other heart conditions. Results: There were 113 consanguineous parents. No relation was found between the types of consanguineous marriages and CHD incidence. Atrial septal defect (ASD) was the most common heart condition among consanguineous marriages seen in 73 patients. Parents with congenital heart diseases had ASD or Ventricular septal defect( VSD) type septal lesions. There was no relationship between the parents' consanguinity and the presence of CHD in any sibling (p=0.169). In 300 siblings, CHD was present in both patients. The older sibling having CHD increases the risk for the younger one (p<0.05). Of the patients, 827 had noncomplex cardiac lesions, 13 had complex cardiac lesions, and 136 had other cardiac pathological echocardiographic (ECHO) findings. Discussion: Families who have a child with pre-existing CHD should be informed about the possibility of CHD recurrence before pregnancy, and these cases should be examined using fetal ECHO in the prenatal period. Those under risk should be followed up and treated in appropriate centers in terms of CHD.
Açıklama
Anahtar Kelimeler
Consanguinity, Congenital Heart Defects, Sibling, Twins
Kaynak
Annals Of Clinical And Analytical Medicine
WoS Q Değeri
Scopus Q Değeri
Cilt
14
Sayı
4
