Peri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/calcification syndrome in end-stage renal disease patients

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dc.contributor.authorTurkmen, K.
dc.contributor.authorTonbul, H. Z.
dc.contributor.authorErdur, F. M.
dc.contributor.authorGuney, I.
dc.contributor.authorKayikcioglu, H.
dc.contributor.authorAltintepe, L.
dc.contributor.authorOzbek, O.
dc.date.accessioned2024-02-23T13:59:27Z
dc.date.available2024-02-23T13:59:27Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractThoracic peri-aortic fat tissue (PFT) is considered as a metabolically active organ in atherosclerosis. Malnutrition, inflammation and atherosclerosis/calcification (MIAC) are the most commonly encountered risk factors of cardiovascular disease in end-stage renal disease (ESRD) patients. Calcification of the aorta was found to be an important cardiovascular risk marker predicting future events, morbidity and mortality in this population. We aimed to investigate the relationship between PFT, MIAC syndrome and thoracic aortic calcification (TAC) in ESRD patients. Seventy-nine ESRD patients receiving hemodialysis (HD) or peritoneal dialysis (PD) and 20 control subjects were enrolled in this cross-sectional study. PFT and TAC were assessed using a 64-MDCT scanner. Patients with serum albumin < 3.5 g/dL were defined as patients with malnutrition; those with serum C-reactive protein level > 10 mg/L had inflammation, and those with coronary artery calcification score (CACS) > 10 had atherosclerosis/calcification. TAC and PFT were significantly higher in ESRD patients compared with control subjects. There was a statistically significant relationship between PFT and TAC in ESRD patients (r = 0.458, p < 0.0001). PFT was found to be significantly increased when the MIAC components increased. PFT was positively associated with age, BMI, uric acid, hemoglobin and CAC. The multivariate analysis revealed that age and uric acid were independent predictors of increased PFT. Twenty-four (30.4 %) patients had none, 30 (37.9 %) had one component, 17 (21.5 %) had two components, and 8 (10.2 %) had all MIAC components. PFT was highest among patients having all three components (28.6 cm(3)) and lowest among those who do not have the MIAC syndrome (8.54 cm(3)). TAC was highest among patients having all three components (179.2 HU) and lowest among those who do not have the MIAC syndrome (0 HU). We found a relationship between PFT and MIAC syndrome in ESRD patients.en_US
dc.description.sponsorshipERA-EDTA Fellowship programen_US
dc.description.sponsorshipDr. G. A. received grant support form ERA-EDTA Fellowship program.en_US
dc.identifier.doi10.1007/s11255-012-0286-x
dc.identifier.endpage867en_US
dc.identifier.issn0301-1623
dc.identifier.issn1573-2584
dc.identifier.issue3en_US
dc.identifier.pmid23001639en_US
dc.identifier.scopus2-s2.0-84879465134en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage857en_US
dc.identifier.urihttps://doi.org/10.1007/s11255-012-0286-x
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11197
dc.identifier.volume45en_US
dc.identifier.wosWOS:000320843400039en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofInternational Urology And Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectEnd-Stage Renal Diseaseen_US
dc.subjectPeriaortic Faten_US
dc.subjectMalnutritionen_US
dc.subjectInflammationen_US
dc.subjectVascular Calcificationen_US
dc.titlePeri-aortic fat tissue and malnutrition-inflammation-atherosclerosis/calcification syndrome in end-stage renal disease patientsen_US
dc.typeArticleen_US

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