Index of cardiac-electrophysiological balance and the effects of thrombolytic therapy on the electrocardiogram of patients with pulmonary embolism

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dc.contributor.authorAlsancak, Yakup
dc.contributor.authorSahin, Ahmet Taha
dc.contributor.authorGurbuz, Ahmet Seyfeddin
dc.contributor.authorSertdemir, Ahmet Lutfi
dc.contributor.authorIcli, Abdullah
dc.contributor.authorAkilli, Hakan
dc.contributor.authorDuzenli, Mehmet Akif
dc.date.accessioned2024-02-23T14:32:12Z
dc.date.available2024-02-23T14:32:12Z
dc.date.issued2020
dc.departmentNEÜen_US
dc.description.abstractOBJECTIVE: Different parameters on electrocardiograms (ECG) have been investigated to predict arrhythmia and mortality in patients with acute pulmonary embolism (APE). The acute effect of thrombolytic therapy (TT) on these parameters has not been investigated yet. METHODS: We examined the data of 83 patients who were evaluated as high-risk APE and discharged from the hospital after TT First, the high-risk APE patients' ECGs were compared with healthy control subjects (n = 55). After their admission and 24 hours later, the ECGs of patients with APE were compared. Heart rate, P-wave morphology, QRS duration, QT distance, Tp-e, and the index of cardiac electrophysiological balance (iCEB) were analyzed. RESULTS: Although P maximum was not different between the groups' ECGs, heart rate, QT, QTc (corrected QT) interval, Tp-e intervals, Tp-e/QT ratio, and P wave dispersion were significantly higher in the APE group (P values < 0.031). iCEB or iCEBc (corrected iCEB) values were lower in APE group (P < 0.001). After TT, we determined a decrease in heart rate, Tp-e interval, and Tp-e/QT ratio (P < 0.001). Although we detected a decrease in the QT and QTc interval and QT dispersion (QTd), QTd had no statistical significance (respectively P-value 0.013, 0.029, and 0.096). The iCEB and iCEBc levels were lower after TT (P-value was 0.035 and 0.044 respectively). CONCLUSION: The QT, QTc, Tp-e interval, Tp-e/QTc ratio, iCEB, and iCEBc values significantly decreased after TT It may be thought that effective TT causes partial improvement in ventricular repolarization in an early period.en_US
dc.identifier.doi10.1590/1806-9282.66.12.1657
dc.identifier.endpage1665en_US
dc.identifier.issn0104-4230
dc.identifier.issn1806-9282
dc.identifier.issue12en_US
dc.identifier.pmid33331573en_US
dc.identifier.scopus2-s2.0-85098606556en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1657en_US
dc.identifier.urihttps://doi.org/10.1590/1806-9282.66.12.1657
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15540
dc.identifier.volume66en_US
dc.identifier.wosWOS:000599837000012en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Medica Brasileiraen_US
dc.relation.ispartofRevista Da Associacao Medica Brasileiraen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectElectrocardiographyen_US
dc.subjectPulmonary Embolismen_US
dc.subjectThrombolytic Therapyen_US
dc.titleIndex of cardiac-electrophysiological balance and the effects of thrombolytic therapy on the electrocardiogram of patients with pulmonary embolismen_US
dc.typeArticleen_US

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