The investigation of levels of endothelial cell-specific molecule, progranuline, clusterin, and human epididymis protein 4 in the differential diagnosis of malignant pleural effusions

dc.contributor.authorDemirbas, Soner
dc.contributor.authorYerlikaya, Fatma Humeyra
dc.contributor.authorYosunkaya, Sebnem
dc.contributor.authorCan, Ummugulsum
dc.contributor.authorCelalettin, Korkmaz
dc.date.accessioned2024-02-23T14:21:14Z
dc.date.available2024-02-23T14:21:14Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBackground:Progranulin (PGRN), endothelial cell-specific molecule-1, clusterin (CLU), and human epididymis protein 4 (HE-4) are novel proteins reported to have diagnostic and prognostic potential in lung cancer. Here, we aimed to identify the markers with high sensitivity and specificity in distinguishing malignant pleural fluids from other pleural fluids. Methods:This prospective, descriptive study was conducted at a medical faculty hospital between 2016 and 2019. The study population consisted of 90 patients <18 years of age with pleural effusion (PE). Levels of pleural fluids of PGRN, endothelial cell-specific molecule-1, CLU, and HE-4 were measured with enzyme-linked immunosorbent assay kits under the manufacturer's manual. Results:Of 90 patients, 54 were men, and 36 were women (mean age 65 +/- 16 years). Of pleural fluids investigated, 23 (25%) and 67 (74%) were transudates and exudates, respectively. Of exudates, while 27 (40%) and 19 (28%) were parapneumonic PE and tuberculous PE, respectively, 20 (29%) were malignant pleural effusion (MPE). Levels of all biomarkers in exudate fluids were found significantly higher than those of transudate fluids. CLU, HE-4, and PGRN levels in MPE were also found significantly higher than benign fluids (P < .05). Cutoff values were achieved by receiver operating characteristics analysis for CLU, HE-4, and PGRN to distinguish between malignant and benign groups. For diagnosis of MPE, the sensitivity and specificity values were found as 0.66 and 0.67 for a cutoff value of CLU of 18.29 mg/L (P = .00), as 0.76 and 0.76 for a cutoff value of HE-4 of 9.33 mg/L (P = .00), and as 0.66 and 0.67 for a cutoff value of PGRN of 105.91 mg/L (P = .001). Conclusion:HE-4 having high sensitivity and specificity can be a potential diagnostic marker in distinguishing between malignant and benign effusions, and these findings can constitute a basis for future research.en_US
dc.identifier.doi10.1097/MD.0000000000032471
dc.identifier.issn0025-7974
dc.identifier.issn1536-5964
dc.identifier.issue52en_US
dc.identifier.pmid36595996en_US
dc.identifier.scopus2-s2.0-85145430658en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.urihttps://doi.org/10.1097/MD.0000000000032471
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13505
dc.identifier.volume101en_US
dc.identifier.wosWOS:000906956700113en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofMedicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectClusterinen_US
dc.subjectEndothelial Cell-Specific Moleculeen_US
dc.subjectHuman Epididymis-4en_US
dc.subjectMalignant Pleural Effusionen_US
dc.titleThe investigation of levels of endothelial cell-specific molecule, progranuline, clusterin, and human epididymis protein 4 in the differential diagnosis of malignant pleural effusionsen_US
dc.typeArticleen_US

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