Mean Platelet Volume as a Potential Predictor of Cholesteatoma in Children

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dc.contributor.authorEryilmaz, Mehmet Akif
dc.contributor.authorDerin, Serhan
dc.date.accessioned2024-02-23T14:23:29Z
dc.date.available2024-02-23T14:23:29Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractObjectives:Cholesteatoma is a chronic inflammatory clinical disorder, and it may cause hearing loss and various complications due to its destructive nature. Mean platelet volume (MPV) is a prothrombotic and proinflammatory marker. The aim of this study is to investigate predictive values of MPV, neutrophil-to-lymphocyte ratio, erythrocyte distribution width, and platelet lymphocyte ratio in cholesteatomatous or noncholesteatomatous pediatric chronic otitis media.Methods:In this study, the authors retrospectively analyzed 24 patients with cholesteatomatous chronic otitis media, 9 patients with noncholesteatomatous chronic otitis media, and 36 age- and sex-matched healthy controls. Cholesteatomatous and noncholesteatomatous chronic otitis media groups were compared with each other, and with controls for WBC, MPV, erythrocyte distribution width, neutrophil-to-lymphocyte ratio, and platelet lymphocyte ratio.Results:Mean platelet volume was significantly lower in patients with cholesteatoma (8.171.22 fL) compared with the control group (10.42 +/- 0.87 fL) (P<0.001). Region of conversion curve analysis showed that the cutoff level of 9.5 fL for MPV was an independent predictor for cholesteatoma with a high sensitivity (86%) and specificity (84%). Cholesteatomatous and noncholesteatomous chronic otitis media patients were similar for other parameters studied.Conclusion:Mean platelet volume may be used as a fast-to-obtain, reliable, and inexpensive marker with a high predictive level to indicate cholesteatoma in children.en_US
dc.identifier.doi10.1097/SCS.0000000000002881
dc.identifier.endpageE578en_US
dc.identifier.issn1049-2275
dc.identifier.issn1536-3732
dc.identifier.issue6en_US
dc.identifier.pmid27526246en_US
dc.identifier.scopus2-s2.0-84981714694en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE575en_US
dc.identifier.urihttps://doi.org/10.1097/SCS.0000000000002881
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13570
dc.identifier.volume27en_US
dc.identifier.wosWOS:000384271100029en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofJournal Of Craniofacial Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectInflammationen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectPediatric Cholesteatomaen_US
dc.titleMean Platelet Volume as a Potential Predictor of Cholesteatoma in Childrenen_US
dc.typeArticleen_US

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