Early severe anemia as the first sign of cystic fibrosis

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dc.contributor.authorSismanlar, Tugba
dc.contributor.authorAslan, Ayse Tana
dc.contributor.authorKose, Mehmet
dc.contributor.authorPekcan, Sevgi
dc.contributor.authorEzgu, Fatih Suheyl
dc.contributor.authorBudakoglu, Isil Irem
dc.contributor.authorYenicesu, Idil
dc.date.accessioned2024-02-23T13:43:49Z
dc.date.available2024-02-23T13:43:49Z
dc.date.issued2016
dc.departmentNEÜen_US
dc.description.abstractSevere anemia is reported to occur rarely in patients with cystic fibrosis (CF). This study aimed to determine the factors associated with early severe anemia in infants with CF. This study included 231 infants with CF from 3 pediatric CF centers ten year period that were retrospectively reviewed in terms of severe anemia as the first sign of CF. Factors that could affect anemia, such as age, pancreatic insufficiency, mutations, vitamin A and E, and albumin level were evaluated. Clinical and laboratory findings in CF patients that presented with severe anemia and no respiratory symptoms were compared to those in CF patients that did not present with severe anemia. Severe anemia as the first sign of CF was noted in 17 of 231 patients. Patient age, prolonged PT/INR and the albumin level differed significantly between the 2 groups of patients (P < 0.001). Feeding pattern, pancreatic insufficiency, vitamin E and A levels, and the types of genetic mutations did not differ between the 2 groups. The mean hemoglobin level was 5.59 +/- 0.21 g/dL and respiratory symptoms began a mean 6.3 months after diagnosis of CF in the anemia group. Conclusion: In early infancy severe anemia in the absence of respiratory symptoms can be the first sign of CF. CF should be considered in the differential diagnosis of severe anemia in infants. Anemia can occur several months before respiratory symptoms in patients with CF and may be caused due to several reasons.en_US
dc.identifier.doi10.1007/s00431-016-2752-4
dc.identifier.endpage1163en_US
dc.identifier.issn0340-6199
dc.identifier.issn1432-1076
dc.identifier.issue9en_US
dc.identifier.pmid27496146en_US
dc.identifier.scopus2-s2.0-84982949187en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1157en_US
dc.identifier.urihttps://doi.org/10.1007/s00431-016-2752-4
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10940
dc.identifier.volume175en_US
dc.identifier.wosWOS:000382696500004en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Pediatricsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnemiaen_US
dc.subjectCystic Fibrosisen_US
dc.subjectInfanten_US
dc.titleEarly severe anemia as the first sign of cystic fibrosisen_US
dc.typeArticleen_US

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