Subclinical Corneal Nerve Fiber Damage and Immune Cell Activation in Systemic Lupus Erythematosus: A Corneal Confocal Microscopy Study

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dc.contributor.authorBitirgen, Gulfidan
dc.contributor.authorKucuk, Adem
dc.contributor.authorErgun, Mustafa Cagri
dc.contributor.authorBaloglu, Ruveyda
dc.contributor.authorGharib, Miral H.
dc.contributor.authorAl Emadi, Samar
dc.contributor.authorPonirakis, Georgios
dc.date.accessioned2024-02-23T14:26:47Z
dc.date.available2024-02-23T14:26:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractPurpose: The purpose of this study was to evaluate the utility of corneal confocal microscopy (CCM) in identifying small nerve fiber damage and immune cell activation in patients with systemic lupus erythematosus (SLE). Methods: This cross-sectional comparative study included 39 consecutive patients with SLE and 30 healthy control participants. Central corneal sensitivity was assessed using a Cochet-Bonnet contact corneal esthesiometer and a laser scanning CCM (Heidelberg, Germany) was used to quantify corneal nerve fiber density (CNFD), nerve branch density (CNBD), nerve fiber length (CNFL), and Langerhans cell (LC) density. Results: Age was comparable among patients with SLE (33.7 +/- 12.7) and controls (35.0 +/- 13.7 years, P = 0.670) and the median duration of disease was 3.0 years (2.0-10.0 years). CNBD (P = 0.003) and CNFL (P = 0.019) were lower and mature LC density (P = 0.002) was higher, but corneal sensitivity (P = 0.178) and CNFD (P = 0.198) were comparable in patients with SLE compared with controls. The SELENA-SLEDAI score correlated with CNFD (rho = -0.319, P = 0.048) and CNFL (rho = -0.373, P = 0.019), and the total and immature LC densities correlated with CNBD (rho = -0.319. P = 0.048, and rho = -0.328, P = 0.041, respectively). Immature LC density was higher (P = 0.025), but corneal sensitivity and nerve fiber parameters were comparable between patients with (33%) and without neuropsychiatric symptoms and SLE. Conclusions: Corneal confocal microscopy identifies distal corneal nerve fiber loss and increased immune cell density in patients with SLE and corneal nerve loss was associated with disease activity. Translational Relevance: Corneal confocal microscopy may enable the detection of subclinical corneal nerve loss and immune cell activation in SLE. Translational Relevance: Corneal confocal microscopy may enable the detection of subclinical corneal nerve loss and immune cell activation in SLE.en_US
dc.identifier.doi10.1167/tvst.10.14.10
dc.identifier.issn2164-2591
dc.identifier.issue14en_US
dc.identifier.pmid34905000en_US
dc.identifier.scopus2-s2.0-85122770783en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1167/tvst.10.14.10
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14336
dc.identifier.volume10en_US
dc.identifier.wosWOS:000731623000001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAssoc Research Vision Ophthalmology Incen_US
dc.relation.ispartofTranslational Vision Science & Technologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCorneal Confocal Microscopyen_US
dc.subjectCorneal Nerve Damageen_US
dc.subjectCorneal Sensitivityen_US
dc.subjectLangerhans Cell Densityen_US
dc.subjectSystemic Lupus Erythematosusen_US
dc.titleSubclinical Corneal Nerve Fiber Damage and Immune Cell Activation in Systemic Lupus Erythematosus: A Corneal Confocal Microscopy Studyen_US
dc.typeArticleen_US

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