Effect of ultrasound treatment on bacteriostatic activity of piezoelectric PHB-TiO2 hybrid biodegradable scaffolds prepared by electrospinning technique

Basit Öğe Kaydı
dc.contributor.authorSarripek, Fatma Bayram
dc.contributor.authorOzaytekin, Ilkay
dc.contributor.authorErci, Fatih
dc.date.accessioned2024-02-23T11:23:31Z
dc.date.available2024-02-23T11:23:31Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractIn this study, biodegradable piezoelectric poly(3-hydroxybuthyrate) (PHB) and PHB-TiO2 as well as non-piezoelectric poly(e-caprolactone) (PCL) fibrous scaffolds were successfully fabricated. First, TiO2 nanoparticles (NPs) with various content (1%, 2%, and 3% wt) were loaded into the PHB matrix to improve its tensile and wettability properties as well as piezoelectric performances. The piezoelectric property of the fibrous scaffolds was examined and a significant improvement in the piezoelectric property of hybrid fibrous scaffolds compared to pure PHB was detected. For the PHB-2%TiO2 sample, a maximum of in the range 4.5-5 V electricity production from a height of 10 cm and a mass drop of 35 g was observed after 150 degrees C heat treatment. Then, an in vitro bactericidal analysis was carried out to test the bacteriostatic effect of the produced piezoelectric biomaterials against E-cherichia coli (E coli) under ultrasound treatment. It was observed that E. coli appeared to be the most sensitive to the PHB-%2TiO(2) sample and consequently the antibacterial activity of all the samples against E. coli was dependent on the piezoelectric properties of the samples. The results indicated that the fabricated fibrous scaffolds could be considered as a promising piezoelectric biomaterial with ultrasonically-controlled bacteriostatic activity for various tissue engineering applications.en_US
dc.identifier.doi10.1002/app.53437
dc.identifier.issn0021-8995
dc.identifier.issn1097-4628
dc.identifier.issue6en_US
dc.identifier.scopus2-s2.0-85142604462en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1002/app.53437
dc.identifier.urihttps://hdl.handle.net/20.500.12452/10527
dc.identifier.volume140en_US
dc.identifier.wosWOS:000890858200001en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofJournal Of Applied Polymer Scienceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectBacteriostatic Activityen_US
dc.subjectPhben_US
dc.subjectPiezoelectric Biomaterialsen_US
dc.subjectScaffoldsen_US
dc.subjectTio2en_US
dc.subjectUltrasounden_US
dc.titleEffect of ultrasound treatment on bacteriostatic activity of piezoelectric PHB-TiO2 hybrid biodegradable scaffolds prepared by electrospinning techniqueen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu