Predicting the outcome of COVID-19 infection in kidney transplant recipients

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dc.contributor.authorOto, Ozgur Akin
dc.contributor.authorOzturk, Savas
dc.contributor.authorTurgutalp, Kenan
dc.contributor.authorArici, Mustafa
dc.contributor.authorAlpay, Nadir
dc.contributor.authorMerhametsiz, Ozgur
dc.contributor.authorSipahi, Savas
dc.date.accessioned2024-02-23T14:27:17Z
dc.date.available2024-02-23T14:27:17Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackgroundWe aimed to present the demographic characteristics, clinical presentation, and outcomes of our multicenter cohort of adult KTx recipients with COVID-19.MethodsWe conducted a multicenter, retrospective study using data of patients hospitalized for COVID-19 collected from 34 centers in Turkey. Demographic characteristics, clinical findings, laboratory parameters (hemogram, CRP, AST, ALT, LDH, and ferritin) at admission and follow-up, and treatment strategies were reviewed. Predictors of poor clinical outcomes were analyzed. The primary outcomes were in-hospital mortality and the need for ICU admission. The secondary outcome was composite in-hospital mortality and/or ICU admission.ResultsOne hundred nine patients (male/female: 63/46, mean age: 48.412.4years) were included in the study. Acute kidney injury (AKI) developed in 46 (42.2%) patients, and 4 (3.7%) of the patients required renal replacement therapy (RRT). A total of 22 (20.2%) patients were admitted in the ICU, and 19 (17.4%) patients required invasive mechanical ventilation. 14 (12.8%) of the patients died. Patients who were admitted in the ICU were significantly older (age over 60years) (38.1% vs 14.9%, p=0.016). 23 (21.1%) patients reached to composite outcome and these patients were significantly older (age over 60years) (39.1% vs. 13.9%; p=0.004), and had lower serum albumin (3.4g/dl [2.9-3.8] vs. 3.8g/dl [3.5-4.1], p=0.002), higher serum ferritin (679 mu g/L [184-2260] vs. 331 mu g/L [128-839], p=0.048), and lower lymphocyte counts (700/mu l [460-950] vs. 860 /mu l [545-1385], p=0.018). Multivariable analysis identified presence of ischemic heart disease and initial serum creatinine levels as independent risk factors for mortality, whereas age over 60years and initial serum creatinine levels were independently associated with ICU admission. On analysis for predicting secondary outcome, age above 60 and initial lymphocyte count were found to be independent variables in multivariable analysis.Conclusion Over the age of 60, ischemic heart disease, lymphopenia, poor graft function were independent risk factors for severe COVID-19 in this patient group. Whereas presence of ischemic heart disease and poor graft function were independently associated with mortality.en_US
dc.identifier.doi10.1186/s12882-021-02299-w
dc.identifier.issn1471-2369
dc.identifier.issue1en_US
dc.identifier.pmid33740915en_US
dc.identifier.scopus2-s2.0-85102840704en_US
dc.identifier.urihttps://doi.org/10.1186/s12882-021-02299-w
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14533
dc.identifier.volume22en_US
dc.identifier.wosWOS:000631175500002en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherBmcen_US
dc.relation.ispartofBmc Nephrologyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectKidney Transplantationen_US
dc.subjectCovid-19en_US
dc.subjectRegistryen_US
dc.titlePredicting the outcome of COVID-19 infection in kidney transplant recipientsen_US
dc.typeArticleen_US

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