MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels in epidermoid lung cancer

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dc.contributor.authorOncel, Mufide
dc.contributor.authorAkoz, Mehmet
dc.contributor.authorOncel, Murat
dc.contributor.authorKiyici, Aysel
dc.contributor.authorApiliogullari, Burhan
dc.date.accessioned2024-02-23T14:37:21Z
dc.date.available2024-02-23T14:37:21Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractAim: To investigate serum levels of MMP-2, TIMP-2, and MMP-2/TIMP-2 complex in epidermoid lung cancer and determine whether one of these markers or any combination of them can be used as a prognostic factor and in the management of this disease. Materials and methods: Twenty-eight patients with non-small cell lung cancer and 21 healthy, age-matched individuals participated in this study. MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were measured in the sera of the patients and controls with the ELISA technique. Results: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels were significantly elevated in patients with non-small cell lung cancer compared to the controls (P = 0.018, 0.041, and 0.034, respectively). Conclusion: MMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels increased not only in lung tissues, but in the sera of the patients with non-small cell lung cancer. However, further studies are needed to fully evaluate the expression rates and diagnostic efficiency of these parameters in different histopathological subtypes of this cancer and in prospective research with a large number of participants.en_US
dc.identifier.doi10.3906/sag-1203-61
dc.identifier.endpage109en_US
dc.identifier.issn1300-0144
dc.identifier.issn1303-6165
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-84872794119en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage104en_US
dc.identifier.urihttps://doi.org/10.3906/sag-1203-61
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16067
dc.identifier.volume43en_US
dc.identifier.wosWOS:000321227400019en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherTubitak Scientific & Technological Research Council Turkeyen_US
dc.relation.ispartofTurkish Journal Of Medical Sciencesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectEpidermoid Lung Canceren_US
dc.subjectMmp-2en_US
dc.subjectTimp-2en_US
dc.subjectMmp-2/Timp-2 Complexen_US
dc.titleMMP-2, TIMP-2, and MMP-2/TIMP-2 complex levels in epidermoid lung canceren_US
dc.typeArticleen_US

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