The comparison of preemptive analgesic effects of curcumin and diclofenac

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dc.contributor.authorAtalik, Nurullahoglu K. E.
dc.contributor.authorOkudan, N.
dc.contributor.authorBelviranli, M.
dc.contributor.authorOz, M.
dc.date.accessioned2024-02-23T14:37:58Z
dc.date.available2024-02-23T14:37:58Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: Preemptive analgesia is an antinociceptive treatment that prevents central sensitization. Antinociceptive effects of diclofenac are well-known. The aim of this study was to investigate preemptive analgesic effects of curcumin and diclofenac, before acute and inflammatory induced pain in rat model. Material and methods: Fourty eight old female (n = 6 in each group) Wistar Albino rats were included in the study. Paw movements in response to paw flinching in response to formalin injection or thermal stimulation were compared after curcumin (400 mg kg(-1), p.o.) and diclofenac (10 mg kg(-1), i.p.) administration. Saline was used as a control. The solvent ethanol was administered in another group of rats. Preemptive analgesic effect was significant in both tests when curcumin and diclofenac was administrated before the pain stimuli. Results: Oral administration of curcumin and intraperitoneal injection of diclofenac increase the response time in hot plate test and decrease the number of flinches in formalin test (p < 0.001 vs p < 0.05). Conclusion: These results suggest that curcunnin had preemptive analgesic effects on acute thermal, and inflammatory induced pain in rats as diclofenac (Fig. 2, Ref. 35). Text in PDF www.elis.sk.en_US
dc.identifier.doi10.4149/BLL_2014_146
dc.identifier.endpage760en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue12en_US
dc.identifier.pmid25520223en_US
dc.identifier.scopus2-s2.0-84921371086en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage757en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2014_146
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16313
dc.identifier.volume115en_US
dc.identifier.wosWOS:000348244100005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherComenius Univen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCurcuminen_US
dc.subjectDiclofenacen_US
dc.subjectPreemptive Analgesic Effecten_US
dc.subjectRaten_US
dc.titleThe comparison of preemptive analgesic effects of curcumin and diclofenacen_US
dc.typeArticleen_US

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