Factors affecting survival in glioblastoma patients below and above 65 years of age: A retrospective observational study

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dc.contributor.authorYavuz, Berrin B.
dc.contributor.authorKanyilmaz, Gul
dc.contributor.authorAktan, Meryem
dc.date.accessioned2024-02-23T14:37:47Z
dc.date.available2024-02-23T14:37:47Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: The purpose of this study is to identify the differences with respect to survival and prognostic factors in a comparison between radiotherapy-receiving glioblastoma (GBM) patients above and below 65 years of age. Methods: The results of 157 patients with GBM were analyzed retrospectively. Patients were divided into two groups as those below and above 65 years of age. A comparison was drawn with respect to each group's demographic characteristics, treatment methods, and findings. Results: Out of a total of 157 patients, 53 patients (33.8%) were above 65 years of age. Karnofsky performance status (KPS) was weaker among older patients (P = 0.002). On the other hand, with respect to radiotherapy dose, among older patient group, greater hypofractionation and whole-brain radiotherapy was applied (P = 0.003) compared with younger patients. The survival rates for 1, 2, and 5 years among patients aged <65 years were 63%, 30%, and 3%, respectively, and in patients aged >= 65 years were 43%, 13%, and 0%, respectively. In univariate analyses, a comparison between patients below and above 65 years of age revealed that values higher than 80 KPS (P = 0.002), applying total excision (P < 0.001), receiving concurrent chemotherapy (P = 0.004), receiving conventional radiotherapy (P < 0.001), and adjuvant chemotherapy (P < 0.001) were effective factors on overall survival rates. Conclusion: In the patient group above 65 years of age, the patient should be attentively selected before opting for a specific treatment, age alone should not be the sole determinant factor. Rather, by considering the KPS scores, potential aggressive treatment options should also be applied.en_US
dc.identifier.doi10.4103/ijc.IJC_36_19
dc.identifier.endpage216en_US
dc.identifier.issn0019-509X
dc.identifier.issn1998-4774
dc.identifier.issue2en_US
dc.identifier.pmid33402568en_US
dc.identifier.scopus2-s2.0-85108021473en_US
dc.identifier.scopusqualityQ4en_US
dc.identifier.startpage210en_US
dc.identifier.urihttps://doi.org/10.4103/ijc.IJC_36_19
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16238
dc.identifier.volume58en_US
dc.identifier.wosWOS:000661269600011en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofIndian Journal Of Canceren_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectGlioblastomaen_US
dc.subjectOlder Patienten_US
dc.subjectRadiotherapyen_US
dc.subjectSurvivalen_US
dc.titleFactors affecting survival in glioblastoma patients below and above 65 years of age: A retrospective observational studyen_US
dc.typeArticleen_US

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