Placental and Umbilical Cord Blood Oxidative Stress Level and Telomere Homeostasis in Early Onset Severe Preeclampsia

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dc.contributor.authorBaser, Emre
dc.contributor.authorInandiklioglu, Nihal
dc.contributor.authorKirmizi, Demet Aydogan
dc.contributor.authorErcan, Fedi
dc.contributor.authorCaniklioglu, Aysen
dc.contributor.authorKara, Mustafa
dc.contributor.authorOnat, Taylan
dc.date.accessioned2024-02-23T14:16:50Z
dc.date.available2024-02-23T14:16:50Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective Although the etiopathogenesis of preeclampsia (PE) is unknown, evidence suggests that it may be associated with increased oxidative stress. Studies have shown that oxidative stress can affect DNA fragments called telomeres. However, the interactions of PE, oxidative stress, and telomere length are not clearly known. This study aims to evaluate the oxidative/anti-oxidative stress balance in the placenta and umbilical cord and examine the effect of oxidative stress on telomeres. Materials-Method Cord blood and placental samples were collected from 27 pregnant women with severe PE (28 (0/7) -33 (6/7) gestational weeks) and 53 healthy pregnant women. Telomere length (TL) was measured by real-time PCR in the cord blood and placenta tissue. Total antioxidant status (TAS) and total oxidant status (TOS) levels were measured in the cord blood and placenta tissue using a colorimetric method. Results No significant differences were found between groups regarding age, BMI, gravida, parity, and newborn gender (p>0.05). Cord blood and placental TL of PE patients were significantly shorter than the control group, while cord blood and placental TAS and TOS levels were higher (p<0.05). The results of a multivariate logistic regression analysis showed that the level of placental TOS in PE patients (OR=1.212, 95% CI=1.068-1.375) was an independent risk factor affecting PE. Conclusion This study found that oxidative stress is an independent risk factor in the development of PE and shortens TL in both placental and umbilical cord blood. Future research on telomere homeostasis may offer a new perspective for the treatment of PE.en_US
dc.identifier.doi10.1055/a-1938-0010
dc.identifier.endpage119en_US
dc.identifier.issn0948-2393
dc.identifier.issn1439-1651
dc.identifier.issue2en_US
dc.identifier.pmid36216345en_US
dc.identifier.scopus2-s2.0-85140474651en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage112en_US
dc.identifier.urihttps://doi.org/10.1055/a-1938-0010
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12827
dc.identifier.volume227en_US
dc.identifier.wosWOS:000865582200004en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofZeitschrift Fur Geburtshilfe Und Neonatologieen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPreeclampsiaen_US
dc.subjectTelomere Lengthen_US
dc.subjectOxidative Stressen_US
dc.subjectTasen_US
dc.subjectTosen_US
dc.titlePlacental and Umbilical Cord Blood Oxidative Stress Level and Telomere Homeostasis in Early Onset Severe Preeclampsiaen_US
dc.typeArticleen_US

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