Assessing eco-toxicological effects of industrial 2,4-D acid iso-octylester herbicide on rat pancreas and liver

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dc.contributor.authorKalipci, E.
dc.contributor.authorOzdemir, C.
dc.contributor.authorOztas, H.
dc.date.accessioned2024-02-23T14:34:37Z
dc.date.available2024-02-23T14:34:37Z
dc.date.issued2013
dc.departmentNEÜen_US
dc.description.abstractWe studied the eco-toxic and carcinogenic effects of a commonly used 2,4-D acid iso-octylester herbicide on rat liver and pancreas. The rats in Group 1 were fed a standard feed and the rats in Group 2 were fed with standard feed to which was added 200 mg/kg/day 2,4-D acid iso-octylester for 16 weeks. Azaserine, 30 mg/kg/body weight, was injected into rats of Groups 3 and 4 to investigate the effects of 2,4-D acid iso-octylester on the development of neoplasms. After feeding the rats with neoplasms in Group 4 with food including 200 mg/kg/day 2,4-D acid iso-octylester for 16 weeks, an autopsy was carried out on all animals. We found that 2,4-D acid iso-octylester caused the formation of atypical cell foci (ACF) in the pancreata and livers of rats. ACF that were formed experimentally by exposure to azaserine had increased diameter, volume and number of atypical cell foci/mm 2 and mm 3 after exposure to 2,4-D acid iso-octylester. Our observations indicated that this herbicide potentially is a cancer initiator.en_US
dc.description.sponsorshipScientific Research Found (BAP) of Selcuk University [09101055]en_US
dc.description.sponsorshipThis work was supported by Scientific Research Found (BAP) of Selcuk University (Grate number: 09101055).en_US
dc.identifier.doi10.3109/10520295.2012.758312
dc.identifier.endpage207en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue3.Nisen_US
dc.identifier.pmid23398176en_US
dc.identifier.scopus2-s2.0-84876499644en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage202en_US
dc.identifier.urihttps://doi.org/10.3109/10520295.2012.758312
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15672
dc.identifier.volume88en_US
dc.identifier.wosWOS:000321904500010en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject2,4-D Acid Iso-Octylesteren_US
dc.subjectAtypical Cell Focien_US
dc.subjectEco-Toxic Effectsen_US
dc.subjectHerbicideen_US
dc.subjectLiveren_US
dc.subjectPancreasen_US
dc.titleAssessing eco-toxicological effects of industrial 2,4-D acid iso-octylester herbicide on rat pancreas and liveren_US
dc.typeArticleen_US

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