The Association of Cataract and Lens Epithelial Cell Apoptosis in Patients with Pseudoexfoliation Syndrome

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dc.contributor.authorOltulu, Pembe
dc.contributor.authorOltulu, Refik
dc.date.accessioned2024-02-23T14:17:18Z
dc.date.available2024-02-23T14:17:18Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractPurpose: The aim of this study was to measure the density of apoptotic lens epithelial cells (LECs) and to determine its association with cataract formation in eyes with pseudoexfoliation syndrome (PEX). Materials and Methods: Twenty-one eyes of 21 patients diagnosed with PEX without glaucoma (Group 1) and 22 eyes of 22 subjects without PEX (Group 2) were enrolled in this study. During cataract surgery, anterior capsule samples were obtained by the 5.5mm continuous curvilinear capsulorhexis method. Apoptosis was determined with a TUNEL kit (Boster, Wuhan, China) according to the manufacturer's protocol. Four fields in each pathology preparation were chosen randomly under a microscope, and 100 cells were counted in each field to calculate the apoptosis rates. Results: Forty-three eyes of 43 subjects were enrolled in this study. There were no significant differences in age or sex between the two studied groups (p > 0.05). Under a microscope, the LECs were stained light blue and their nuclei were oval shaped. Positive stained cells were found occasionally in Group 2, while a significant amount of black-brown positively stained LECs with condensed nuclei was found in Group 1. The apoptosis rates were 35.2 +/- 2.1% and 14.1 +/- 1% in Groups 1 and 2, respectively. The proportion of positively stained LECs was higher in Group 1 (p < 0.001). Conclusion: Our study suggests that apoptosis in LECs is the pathophysiological mechanism for the higher rate of cataracts in PEX patients, in addition to the ocular ischemia hypothesis.en_US
dc.description.sponsorshipScientific Research Coordination Center of Necmettin Erbakan University [BAP151218019]en_US
dc.description.sponsorshipThis study is supported by The Scientific Research Coordination Center of Necmettin Erbakan University (BAP151218019).en_US
dc.identifier.doi10.1080/02713683.2017.1406524
dc.identifier.endpage303en_US
dc.identifier.issn0271-3683
dc.identifier.issn1460-2202
dc.identifier.issue3en_US
dc.identifier.pmid29182401en_US
dc.identifier.scopus2-s2.0-85035101795en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage300en_US
dc.identifier.urihttps://doi.org/10.1080/02713683.2017.1406524
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13039
dc.identifier.volume43en_US
dc.identifier.wosWOS:000424419400004en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Incen_US
dc.relation.ispartofCurrent Eye Researchen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectApoptosisen_US
dc.subjectPseudoexfoliation Syndromeen_US
dc.subjectLens Epithelial Cellen_US
dc.subjectCataracten_US
dc.subjectTunelen_US
dc.titleThe Association of Cataract and Lens Epithelial Cell Apoptosis in Patients with Pseudoexfoliation Syndromeen_US
dc.typeArticleen_US

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