Nephrotic syndrome induced by cetuximab in a patient with metastatic colorectal cancer

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dc.contributor.authorKorkmaz, Mustafa
dc.contributor.authorHendem, Engin
dc.contributor.authorEryilmaz, Melek Karakurt
dc.contributor.authorDemirkiran, Aykut
dc.contributor.authorKaraagac, Mustafa
dc.contributor.authorArtac, Mehmet
dc.date.accessioned2024-02-23T14:27:02Z
dc.date.available2024-02-23T14:27:02Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractIntroduction Cetuximab, an anti-EGFR monoclonal antibody, often cause skin toxicity, most commonly acneiform rash. We present a rare case of glomerulonephritis associated with cetuximab therapy. Case Report A 58-year-old male patient recently completed cetuximab-based chemotherapy for metastatic colorectal adenocarcinoma. He presented with acute renal failure, anasarca edema and nephrotic proteinuria. The amount of protein in the 24-h urine test was over 15.6 grams. Management & Outcome The patient showed a dramatic improvement in renal function shortly after terminated of cetuximab therapy without immunosuppressive therapy. Discussion Therefore, drugs targeting epidermal growth factor receptor (EGFR) monoclonal antibody were thought to trigger nephrotic syndrome by causing glomerular damage. As a result, physicians using EGFR monoclonal inhibitors should be very careful about renal functions and proteinuria in patients.en_US
dc.identifier.doi10.1177/10781552211073790
dc.identifier.endpage1002en_US
dc.identifier.issn1078-1552
dc.identifier.issn1477-092X
dc.identifier.issue4en_US
dc.identifier.pmid35023411en_US
dc.identifier.scopus2-s2.0-85122864210en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage998en_US
dc.identifier.urihttps://doi.org/10.1177/10781552211073790
dc.identifier.urihttps://hdl.handle.net/20.500.12452/14429
dc.identifier.volume28en_US
dc.identifier.wosWOS:000749318300001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSage Publications Ltden_US
dc.relation.ispartofJournal Of Oncology Pharmacy Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCetuximaben_US
dc.subjectNephrotic Syndromeen_US
dc.subjectColorectal Canceren_US
dc.titleNephrotic syndrome induced by cetuximab in a patient with metastatic colorectal canceren_US
dc.typeArticleen_US

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