Risk for Malignant and Borderline Ovarian Neoplasms Following Basic Preoperative Evaluation by Ultrasonography, Ca125 Level and Age

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dc.contributor.authorKaradag, Burak
dc.contributor.authorKocak, M.
dc.contributor.authorKayikcioglu, F.
dc.contributor.authorErcan, F.
dc.contributor.authorDilbaz, B.
dc.contributor.authorKose, M. F.
dc.contributor.authorHaberal, A.
dc.date.accessioned2024-02-23T14:44:50Z
dc.date.available2024-02-23T14:44:50Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractObjective: To verify the basic preoperative evaluation in the discrimination between benign and malignant adnexal masses in our clinical practice. Materials and Methods: Data were collected on the records of 636 women with adnexal masses who had undergone surgery either by open or endoscopic approaches. Those with obvious signs of malignancy, any history of cancer, emergency surgeries without basic evaluation were excluded. The preoperative features by age, ultrasound and serum Ca125 level were compared with final histopathological diagnosis at the four departments of the institution. These are the general gynecology (Group 1:exploratory laparotomy), the gynecologic endoscopy (Group 2: laparoscopy and adnexectomy), the gynecological oncology (Group 3:staging laparotomy) and the gynecologic endocrinology and infertility (Group 4: laparoscopy and cystectomy). Results: There were simple and complex cyst rates of 22.3% and 77.2%, respectively. There were 86.3% benign, 4.1% (n:20) borderline ovarian tumor (BOT) and 6.4% (n:48) malignant lesions. There were 3 BOT and 9 ovarian cancers in Group 1 and one BOT and two ovarian cancer in the Group 2. During the surgery, 15 BOT (75%) and 37 ovarian cancer (77%) were detected in the Group 3, only one BOT was encountered in the Group 4. The risk of rate of unsuspected borderline or focally invasive ovarian cancer significantly increased by age, size, complex morphology and Ca125 (95% CI, OR=2.72, OR=6.60, OR=6.66 and OR=4.69, respectively). Conclusions: Basic preoperative evaluation by comprehensive ultrasound imaging combined with age and Ca125 level has proved highly accurate for prediction of unexpected malignancies. Neither novel markers nor new imaging techniques provide better information that allow clinicians to assess the feasibility of the planned surgery; consequently, the risk of inadvertent cyst rupture during laparoscopy may be significantly decreased in selected cases.en_US
dc.identifier.doi10.7314/APJCP.2014.15.19.8489
dc.identifier.endpage8493en_US
dc.identifier.issn1513-7368
dc.identifier.issue19en_US
dc.identifier.pmid25339052en_US
dc.identifier.scopus2-s2.0-84924280647en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage8489en_US
dc.identifier.urihttps://doi.org/10.7314/APJCP.2014.15.19.8489
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17133
dc.identifier.volume15en_US
dc.identifier.wosWOS:000343833800076en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAsian Pacific Organization Cancer Preventionen_US
dc.relation.ispartofAsian Pacific Journal Of Cancer Preventionen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdnexal Massesen_US
dc.subjectUltrasonographyen_US
dc.subjectRisk Of Ovarian Canceren_US
dc.subjectLaparoscopic Surgeryen_US
dc.titleRisk for Malignant and Borderline Ovarian Neoplasms Following Basic Preoperative Evaluation by Ultrasonography, Ca125 Level and Ageen_US
dc.typeArticleen_US

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