Evaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorder

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dc.contributor.authorAkinci, Mehmet Akif
dc.contributor.authorUzun, Necati
dc.date.accessioned2024-02-23T14:37:59Z
dc.date.available2024-02-23T14:37:59Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractAIM: This study aims to investigate whether there is a relationship between attention-defi cit/hyperactivity disorder (ADHD) and infl ammation, using hematologic infl ammatory parameters in a large sample of children and adolescents. METHOD: This retrospective study comprises 347 children and adolescents with ADHD between 6 and 17 years of age who met the inclusion criteria as well as 205 healthy children and adolescents in the control group. Serum parameters such as white blood cell (WBC), neutrophil, lymphocyte, platelet, monocyte, eosinophil and basophil counts, mean platelet volume (MPV), and platelet distribution width (PDW) were recorded from complete blood count tests at the time of admission, while neutrophil lymphocyte ratio (NLR), platelet lymphocyte ratio (PLR), and other ratios were calculated based on these counts. RESULTS: NLR, PLR, MPV, PDW, WBC and neutrophil counts were signifi cantly higher in children and adolescents with ADHD than in the control group. In the ADHD group, NLR, WBC and neutrophil counts were signifi cantly higher in girls than in boys. CONCLUSIONS: The results of this study support the hypothesis that infl ammation plays an important role in the complex pathophysiology of ADHD. In addition, our data confi rm that easily obtainable and reliable hematological parameters can be used when investigating the role of infl ammation in ADHD etiology (Tab. 4, Ref. Text in PDF www.elis.sken_US
dc.identifier.doi10.4149/BLL_2021_042
dc.identifier.endpage262en_US
dc.identifier.issn0006-9248
dc.identifier.issn1336-0345
dc.identifier.issue4en_US
dc.identifier.pmid33729818en_US
dc.identifier.scopus2-s2.0-85103143356en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage256en_US
dc.identifier.urihttps://doi.org/10.4149/BLL_2021_042
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16322
dc.identifier.volume122en_US
dc.identifier.wosWOS:000647157300005en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherAepress Sroen_US
dc.relation.ispartofBratislava Medical Journal-Bratislavske Lekarske Listyen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAdhden_US
dc.subjectInflammationen_US
dc.subjectMean Platelet Volumeen_US
dc.subjectNeutrophilen_US
dc.subjectLymphocyte Ratioen_US
dc.subjectPlateleten_US
dc.subjectLymphocyte Ratioen_US
dc.titleEvaluation of hematological inflammatory markers in children and adolescents with attention deficit/hyperactivity disorderen_US
dc.typeArticleen_US

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