Hybrid nanoflowers modified pencil graphite electrodes developed for electrochemical monitoring of interaction between Mitomycin C and DNA

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dc.contributor.authorFindik, Mukerrem
dc.contributor.authorBingol, Haluk
dc.contributor.authorErdem, Arzum
dc.date.accessioned2024-02-23T14:16:20Z
dc.date.available2024-02-23T14:16:20Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractIn the present study, biocompatible hybrid nanoflowers (NFs) were synthesized by amino acids (glycine, L-lysine) via a simple, rapid and cost-effective methods. NFs were characterized by using FT-IR, Raman spectroscopy, XPS, SEM and EDX techniques. Modified pencil graphite electrode (PGE) surfaces with well-defined NFs were developed to electrochemical monitoring of calf thymus double stranded DNA (ctdsDNA) using differential pulse voltammetry (DPV) for the first time. SEM, EDX, cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) methods were used to characterize the surfaces obtained after modification. In comparison to L-lysine NFs (LNFs-PGE), glycine NFs (GNFs-PGE) exhibited a higher sensitivity performance towards the oxidation of guanine moiety signals. The interaction time between anticancer drug Mitomycin C (MC) and ctdsDNA was aslo investigated with GNFs-PGE.en_US
dc.description.sponsorshipScientific and Technological Research Council of Turkey (TUBITAK); Turkish Academy of Sciences (TUBA)en_US
dc.description.sponsorshipM.F. acknowledges the postdoctoral scholarship under 2218-National Postdoctoral Research Fellowship Programme granted by The Scientific and Technological Research Council of Turkey (TUBITAK). A. E. would like to express her gratitude to the Turkish Academy of Sciences (TUBA) as a Principal member for its partial support.en_US
dc.identifier.doi10.1016/j.talanta.2020.121647
dc.identifier.issn0039-9140
dc.identifier.issn1873-3573
dc.identifier.pmid33167275en_US
dc.identifier.scopus2-s2.0-85091238479en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.talanta.2020.121647
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12631
dc.identifier.volume222en_US
dc.identifier.wosWOS:000589941600001en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherElsevieren_US
dc.relation.ispartofTalantaen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectHybrid Nanoflowersen_US
dc.subjectElectrochemical Dna Biosensorsen_US
dc.subjectAnticancer Drug-Dna Interactionen_US
dc.subjectMitomycin Cen_US
dc.subjectPencil Graphite Electrodeen_US
dc.titleHybrid nanoflowers modified pencil graphite electrodes developed for electrochemical monitoring of interaction between Mitomycin C and DNAen_US
dc.typeArticleen_US

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