Detection of nuclear receptors in gingival samples of diabetic and nondiabetic periodontitis patients

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dc.contributor.authorKaratas, O.
dc.contributor.authorYuce, H. Balci
dc.contributor.authorTaskan, M. M.
dc.contributor.authorGevrek, F.
dc.contributor.authorYarkac, F. Ucan
dc.contributor.authorCacan, E.
dc.date.accessioned2024-02-23T14:37:54Z
dc.date.available2024-02-23T14:37:54Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Diabetes and periodontitis are two chronic inflammatory diseases sharing specific etiopathogenetic mechanisms, and both cause severe inflammation and destruction. Aims: The present study aimed to determine the receptor expressions of peroxisome proliferative-activated receptor (PPAR)-gamma, retinoid X receptor (RXR)-alpha, vitamin D receptor (VDR), and nuclear factor kappa B (NF-kappa B) expressions in healthy gingiva and diseased gingival samples with or without diabetes. Methods: Forty-five participants as (1) healthy controls (C), (2) periodontitis group (P), and (3) diabetes and periodontitis group (DP) were enrolled. Plaque index (PI), gingival index (GI), probing depth (PD), clinical attachment levels (CAL), and bleeding on probing (BOP) were recorded in all participants. Two gingival biopsies from each participant were obtained, and one underwent histological tissue processing while the other underwent qRT-PCR analysis of nuclear receptors. Inflammatory and fibroblast cell counts, PPAR-gamma, RXR-alpha, VDR, and NF-kappa B were evaluated. Results: Fibroblast cells were lowest in the DP group and highest in the healthy group. PPAR-gamma, VDR, RXR, and NF-kappa B expressions were higher in the healthy controls in the qRT-PCR analysis and similar in the other groups. Immunohistochemistry analysis also showed similar results. Conclusion: qRT-PCR results concluded that healthy gingival samples had higher PPAR-gamma, RXR, VDR, and NF-kappa B expressions, and immunohistochemistry findings supported the results. In addition, healthy gingiva contained higher fibroblast cells and lower inflammatory cells.en_US
dc.description.sponsorshipTokat Gaziosmanpasa University Scientific Research Uniten_US
dc.description.sponsorshipThe present study was supported by the Tokat Gaziosmanpasa University Scientific Research Unit, and no external funding was available for this study.en_US
dc.identifier.doi10.4103/njcp.njcp_216_20
dc.identifier.endpage276en_US
dc.identifier.issn1119-3077
dc.identifier.issue2en_US
dc.identifier.pmid33605919en_US
dc.identifier.scopus2-s2.0-85101981614en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage269en_US
dc.identifier.urihttps://doi.org/10.4103/njcp.njcp_216_20
dc.identifier.urihttps://hdl.handle.net/20.500.12452/16267
dc.identifier.volume24en_US
dc.identifier.wosWOS:000623686500019en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWolters Kluwer Medknow Publicationsen_US
dc.relation.ispartofNigerian Journal Of Clinical Practiceen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectDiabetesen_US
dc.subjectNf-? Ben_US
dc.subjectPpar-? Periodontitisen_US
dc.subjectRxren_US
dc.subjectVdren_US
dc.titleDetection of nuclear receptors in gingival samples of diabetic and nondiabetic periodontitis patientsen_US
dc.typeArticleen_US

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