Serum annexin A2 levels in acute brucellosis and brucellar spondylodiscitis

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dc.contributor.authorDemir, N. Aktug
dc.contributor.authorKolgelier, S.
dc.contributor.authorSumer, S.
dc.contributor.authorInkaya, A. C.
dc.contributor.authorOzcimen, S.
dc.contributor.authorDemir, L. S.
dc.contributor.authorUral, O.
dc.date.accessioned2024-02-23T13:55:57Z
dc.date.available2024-02-23T13:55:57Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractBrucellosis is a chronic granulomatous infection and may present with various clinical manifestations. Brucellar spondylodiscitis symptoms are initially subtle and nonspecific. Annexin A2 (ANXA2) is involved in various biological functions, including osteoclast formation, bone resorption, and cell growth regulation. In this study, we aimed to determine the clinical significance of serum ANXA2 levels in acute brucellosis and brucellar spondylodiscitis. This prospective study included 96 acute brucellosis patients and 51 healthy controls. Acute brucellosis was diagnosed by a 1/160 or higher titer in a standard tube agglutination (STA) test or a four-fold increase in titers between two STA tests performed two weeks apart in the presence of clinical symptoms within the last eight weeks and/or growth of Brucella spp. in appropriately prepared culture media. ANXA2 levels were determined with an enzyme-linked immunosorbent assay (ELISA). Forty (41.7 %) of 96 acute brucellosis patients were male and 56 (58.3 %) were female. Serum ANXA2 levels were elevated in patients compared to healthy controls (p=0.001). Eighteen of 96 (18.7 %) acute brucellosis patients had brucellar spondylodiscitis. The serum ANXA2 levels of patients with brucellar spondylodiscitis were higher than those of patients with acute disease without brucellar spondylodiscitis (p=0.001). ANXA2, C-reactive protein (CRP), and erythrocyte sedimentation rate (ESR) values were elevated in the brucellar spondylodiscitis group compared to patients without brucellar spondylodiscitis. Serum ANXA2 measurement together with ESR and CRP is thought to be indicative in the diagnosis of brucellar spondylodiscitis, a common complication of brucellosis.en_US
dc.identifier.doi10.1007/s10096-014-2155-2
dc.identifier.endpage1859en_US
dc.identifier.issn0934-9723
dc.identifier.issn1435-4373
dc.identifier.issue10en_US
dc.identifier.pmid24853056en_US
dc.identifier.scopus2-s2.0-84911005250en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage1855en_US
dc.identifier.urihttps://doi.org/10.1007/s10096-014-2155-2
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11031
dc.identifier.volume33en_US
dc.identifier.wosWOS:000343139000025en_US
dc.identifier.wosqualityQ2en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringeren_US
dc.relation.ispartofEuropean Journal Of Clinical Microbiology & Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subject[Keyword Not Available]en_US
dc.titleSerum annexin A2 levels in acute brucellosis and brucellar spondylodiscitisen_US
dc.typeArticleen_US

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