Autophagic mechanisms in longevity intervention: role of natural active compounds

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dc.contributor.authorAkca, Kevser Taban
dc.contributor.authorAyan, Ilknur Cinar
dc.contributor.authorCetinkaya, Sumeyra
dc.contributor.authorSalihoglu, Ece Miser
dc.contributor.authorSuntar, Ipek
dc.date.accessioned2024-02-23T14:16:32Z
dc.date.available2024-02-23T14:16:32Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractThe term 'autophagy' literally translates to 'self-eating' and alterations to autophagy have been identified as one of the several molecular changes that occur with aging in a variety of species. Autophagy and aging, have a complicated and multifaceted relationship that has recently come to light thanks to breakthroughs in our understanding of the various substrates of autophagy on tissue homoeostasis. Several studies have been conducted to reveal the relationship between autophagy and age-related diseases. The present review looks at a few new aspects of autophagy and speculates on how they might be connected to both aging and the onset and progression of disease. Additionally, we go over the most recent preclinical data supporting the use of autophagy modulators as age-related illnesses including cancer, cardiovascular and neurodegenerative diseases, and metabolic dysfunction. It is crucial to discover important targets in the autophagy pathway in order to create innovative therapies that effectively target autophagy. Natural products have pharmacological properties that can be therapeutically advantageous for the treatment of several diseases and they also serve as valuable sources of inspiration for the development of possible new small-molecule drugs. Indeed, recent scientific studies have shown that several natural products including alkaloids, terpenoids, steroids, and phenolics, have the ability to alter a number of important autophagic signalling pathways and exert therapeutic effects, thus, a wide range of potential targets in various stages of autophagy have been discovered. In this review, we summarised the naturally occurring active compounds that may control the autophagic signalling pathways.en_US
dc.identifier.doi10.1017/erm.2023.5
dc.identifier.issn1462-3994
dc.identifier.pmid36994671en_US
dc.identifier.scopus2-s2.0-85153803938en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.urihttps://doi.org/10.1017/erm.2023.5
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12702
dc.identifier.volume25en_US
dc.identifier.wosWOS:000975079500001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherCambridge Univ Pressen_US
dc.relation.ispartofExpert Reviews In Molecular Medicineen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAutophagyen_US
dc.subjectCanceren_US
dc.subjectDiabetesen_US
dc.subjectLongevityen_US
dc.subjectNatural Compoundsen_US
dc.subjectNeurologyen_US
dc.subjectObesityen_US
dc.titleAutophagic mechanisms in longevity intervention: role of natural active compoundsen_US
dc.typeReview Articleen_US

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