The known genetic defects in common variable immunodeficiency

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dc.contributor.authorKara, Reyhan
dc.contributor.authorGokturk, Bahar
dc.contributor.authorAcar, Aynur
dc.date.accessioned2024-02-23T14:45:55Z
dc.date.available2024-02-23T14:45:55Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractCommon variable immunodeficiency (CVID) is a relatively common form of immunodeficiency disorders which constitutes a mixed group of heterogeneous conditions linked by lack of immune globulin production and primary antibody failure. Recently, it is understood that various monogenic defects determine the variability in phenotype and have roles in the immunopathogenesis of CVID. In this review, the molecular defects related to CVID which are ICOS (inducible co-stimulator), TACI (transmembrane activator and calcium-modulator and cyclophilin ligand interactor), CD19, MSH5 (MutS Homologue 5 Mutations), BAFF-R (B cell activating factor receptor), CD20, CD81, CD21, LRBA (lipopolysaccharide-responsive beige-like anchor), and their genetic basis were aimed to be reviewed.en_US
dc.identifier.endpage69en_US
dc.identifier.issn1308-9234
dc.identifier.issue2en_US
dc.identifier.startpage59en_US
dc.identifier.urihttps://hdl.handle.net/20.500.12452/17699
dc.identifier.volume12en_US
dc.identifier.wosWOS:000420883500002en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.language.isotren_US
dc.publisherBilimsel Tip Yayinevien_US
dc.relation.ispartofAstim Allerji Immunolojien_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCommon Variable Immunodeficiencyen_US
dc.subjectGenetic Defectsen_US
dc.subjectPrimary Antibody Deficiencyen_US
dc.titleThe known genetic defects in common variable immunodeficiencyen_US
dc.typeReview Articleen_US

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