Comparison of pre-operative platelet functions by thromboelastogram in patients selective serotonin reuptake inhibitors user and non-user

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dc.contributor.authorYilmaz, Resul
dc.contributor.authorYusifov, Merve
dc.contributor.authorHacibeyoglu, Gulcin
dc.contributor.authorArican, Sule
dc.contributor.authorTopal, Ahmet
dc.date.accessioned2024-02-23T14:31:41Z
dc.date.available2024-02-23T14:31:41Z
dc.date.issued2022
dc.departmentNEÜen_US
dc.description.abstractBACKGROUND: The use of antidepressant drugs, in particular selective serotonin reuptake inhibitors (SSRIs), has increased in recent years. Using SSRIs can cause changes in serotonin metabolism. Serotonin provides platelet aggregation and plays a role in the regulation of vascular tone and coagulation processes. The aim of this study was to evaluate the effects of SSRI use on coagulation functions with thromboelastogram (TEG) in patients undergoing surgical operation and to compare with non-user cases. METHODS: The study was designed for 60 patients whose physical status was classified according to the American Society of Anes-thesiology (ASA) classification as ASA I-II were included in the study. During routine pre-operative blood tests, 2 ml complete blood sample used and TEG performed. The cases were divided into two groups as SSRI user and non-user and analyzed. RESULTS: R value was higher in SSRI user patients than in non-user patients. The MA value was significantly lower in SSRI user. There was no statistically significant difference in other parameters. In the evaluation based on duration of SSRI use, there was no statistically significant difference between those whose duration of use was more than 1 year and <1 year. CONCLUSION: When the coagulation process was evaluated by TEG method, it was seen that the onset of clotting was prolonged and thrombus formation was slowed down in SSRI users. The results did not reveal that SSRI alone was the cause of bleeding, but it was concluded that slowing the process might be important, especially for surgical operations.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Necmettin Erbakan University [171218012]en_US
dc.description.sponsorshipThis project was supported by The Scientific Research Projects Coordinatorship of Necmettin Erbakan University. Project No: 171218012.en_US
dc.identifier.doi10.14744/tjtes.2020.96892
dc.identifier.endpage280en_US
dc.identifier.issn1306-696X
dc.identifier.issn1307-7945
dc.identifier.issue3en_US
dc.identifier.pmid35485575en_US
dc.identifier.scopus2-s2.0-85127524586en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage276en_US
dc.identifier.urihttps://doi.org/10.14744/tjtes.2020.96892
dc.identifier.urihttps://hdl.handle.net/20.500.12452/15312
dc.identifier.volume28en_US
dc.identifier.wosWOS:000764975400007en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTurkish Assoc Trauma Emergency Surgeryen_US
dc.relation.ispartofUlusal Travma Ve Acil Cerrahi Dergisi-Turkish Journal Of Trauma & Emergency Surgeryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectPlatelet Functionsen_US
dc.subjectSelective Serotonin Reuptake Inhibitorsen_US
dc.subjectThromboelastogramen_US
dc.titleComparison of pre-operative platelet functions by thromboelastogram in patients selective serotonin reuptake inhibitors user and non-useren_US
dc.typeArticleen_US

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