Systemic treatment with alpha-tocopherol and/or sodium selenite decreases the progression of experimental periodontitis

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dc.contributor.authorBas, Nurgul
dc.contributor.authorKayar, Nezahat Arzu
dc.contributor.authorBaba, Z. Fusun
dc.contributor.authorAvunduk, Mustafa Cihat
dc.contributor.authorHaliloglu, Seyfullah
dc.contributor.authorAlptekin, Nilgun Ozlem
dc.date.accessioned2024-02-23T13:55:53Z
dc.date.available2024-02-23T13:55:53Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractObjective To investigate the effects of sodium selenite (Se) and/or alpha-tocopherol (alpha T) applications on the alveolar bone loss (ABL), the number of gingival collagen fibers, inducible nitric oxide synthase (iNOS)+ and CD95+ cell numbers, and serum cytokine concentrations in experimental periodontitis in rats. Materials and methods Forty Sprague Dawley rats were divided into four groups of ten as follows: group A: Se group, group B: alpha T group, group C: Se and alpha T combined group, and group D: control group (intraperitoneal (IP) saline injection applied). Using the image analysis method in the connective tissue under the connective epithelium, the numbers of iNOS, CD95 positive cells, and collagen fibers were counted. ELISA kits were used to test the concentrations of serum interleukin (IL)-1 beta, IL-6, and IL-4. Results The combination of Se and alpha T (group C) suppressed ABL compared with the control group (group D) (P< 0.05). In group A (Se), the number of iNOS+ cells was smaller than in group D (P< 0.05). Conclusion Se has been concluded to inhibit inflammation of the gum due to iNOS. Se and alpha T can have a remarkable important role in preventing alveolar bone loss, and particularly in combination.en_US
dc.description.sponsorshipSelcuk University Scientific Research Projects [09102032]en_US
dc.description.sponsorshipThis study was supported by grants from the Selcuk University Scientific Research Projects (09102032).en_US
dc.identifier.doi10.1007/s00784-020-03579-9
dc.identifier.endpage2688en_US
dc.identifier.issn1432-6981
dc.identifier.issn1436-3771
dc.identifier.issue5en_US
dc.identifier.pmid32986166en_US
dc.identifier.scopus2-s2.0-85091689342en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.startpage2677en_US
dc.identifier.urihttps://doi.org/10.1007/s00784-020-03579-9
dc.identifier.urihttps://hdl.handle.net/20.500.12452/11001
dc.identifier.volume25en_US
dc.identifier.wosWOS:000574039200002en_US
dc.identifier.wosqualityQ1en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherSpringer Heidelbergen_US
dc.relation.ispartofClinical Oral Investigationsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAnimal Modelen_US
dc.subjectExperimental Periodontitisen_US
dc.subjectAlpha-Tocopherolen_US
dc.subjectSodium Seleniteen_US
dc.subjectCd95en_US
dc.subjectInosen_US
dc.subjectIl-1 Betaen_US
dc.subjectIl-6en_US
dc.subjectIl-4en_US
dc.titleSystemic treatment with alpha-tocopherol and/or sodium selenite decreases the progression of experimental periodontitisen_US
dc.typeArticleen_US

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