Clinical and Laboratory Evaluations of Patients Diagnosed as Having Multisystem Inflammatory Syndrome Associated with Coronavirus Disease 2019 in Children: A Single Center Experience from Konya

Basit Öğe Kaydı
dc.contributor.authorGenceli, Mustafa
dc.contributor.authorAkcan, Ozge Metin
dc.contributor.authorErdogan, Kubra Nur
dc.contributor.authorKilic, Ahmet Osman
dc.contributor.authorYazar, Abdullah
dc.contributor.authorAkin, Fatih
dc.contributor.authorGunes, Muhammed
dc.date.accessioned2024-02-23T14:17:01Z
dc.date.available2024-02-23T14:17:01Z
dc.date.issued2023
dc.departmentNEÜen_US
dc.description.abstractObjective Multisystem inflammatory syndrome in children (MIS-C), characterized by fever, inflammation, and multiorgan dysfunction, was newly defined after severe acute respiratory syndrome coronavirus 2 infection. The clinical spectrum of MIS-C can be classified as mild, moderate, and severe. We aimed to evaluate demographics, clinical presentations, laboratory findings, and treatment modalities of patients with MIS-C according to clinical severity.Methods We performed a retrospective study of patients who were diagnosed as having MIS-C between September 2020 and October 2021 in the Necmettin Erbakan University Meram Faculty of Medicine, Turkey.Results A total of 48 patients (24 females and 24 males) with a median age at diagnosis of 10.3 years (range: 42 months-17 years) were enrolled, the most common clinical severity of MIS-C was moderate. The common presentations of patients were fever (97%), nonpurulent conjunctivitis (89.6%), rashes (81.3%), fatigue (81.3%), strawberry tongue (79.2%), and myalgia (68.8%). The most common laboratory findings were lymphopenia (81.2%), thrombocytopenia (54.1%), elevated D-dimer levels (89.5%), C-reactive protein (CRP; 100%), procalcitonin (97%), erythrocyte sedimentation rate (87.5%), ferritin (95.8%), interleukin 6 (IL-6) (86.1%), and probrain natriuretic peptide (pro-BNP) (97%). High levels of CRP, procalcitonin, pro-BNP, and urea were associated with the severity of MIS-C ( p < 0.05). Fifteen of the patients were found to have pulmonary involvement. Ascites were the most common finding on abdominal ultrasonography (11 patients) and were not seen in a mild form of the disease. During the study period, two patients died.Conclusion It is important to make patient-based decisions and apply a stepwise approach in treating patients with MIS-C due to the increased risk of complications and mortality.en_US
dc.identifier.doi10.1055/s-0042-1758745
dc.identifier.endpage24en_US
dc.identifier.issn1305-7707
dc.identifier.issn1305-7693
dc.identifier.issue1en_US
dc.identifier.scopus2-s2.0-85144910442en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage17en_US
dc.identifier.urihttps://doi.org/10.1055/s-0042-1758745
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12894
dc.identifier.volume18en_US
dc.identifier.wosWOS:000890880800001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.language.isoenen_US
dc.publisherGeorg Thieme Verlag Kgen_US
dc.relation.ispartofJournal Of Pediatric Infectious Diseasesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMultisystem Inflammatory Syndrome In Childrenen_US
dc.subjectCovid-19en_US
dc.subjectClinical And Laboratory Findingsen_US
dc.titleClinical and Laboratory Evaluations of Patients Diagnosed as Having Multisystem Inflammatory Syndrome Associated with Coronavirus Disease 2019 in Children: A Single Center Experience from Konyaen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu