Effect of pinealectomy and melatonin supplementation on metallothionein, ZnT2, ZIP2, ZIP4 and zinc levels in rat small intestine

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dc.contributor.authorUnal, Omer
dc.contributor.authorBaltaci, Abdulkerim Kasim
dc.contributor.authorMogulkoc, Rasim
dc.contributor.authorAvunduk, Mustafa Cihat
dc.date.accessioned2024-02-23T14:20:29Z
dc.date.available2024-02-23T14:20:29Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractWe investigated the relations among levels of metallothionein (MT); zinc (Zn) transport proteins, ZnT2, ZIP2 (ZRT and IRT-like proteins); and ZIP4, which enable Zn absorption in the small intestine of rats. We also investigated tissue Zn levels in the small intestine. We used four groups of adult male rats: group 1, control; group 2, pinealectomy (Px); group 3, Px + melatonin (MEL); group 4, MEL only. Animals in groups 3 and 4 were administered 5 mg/kg/day MEL for four weeks. At the end of the study, all animals were sacrificed and samples of duodenum, jejunum and ileum were harvested to analyze ZnT2, ZIP2, ZIP4 and MT levels using immunohistochemistry, and tissue Zn levels were measured by atomic absorption spectrophotometry. The lowest ZnT2 levels in the duodenum, jejunum and ileum, and the lowest ZIP2 levels in the duodenum and ileum were found in group 2. The lowest ZIP4 levels were found in the duodenum and jejunum, and the lowest MT levels in the duodenum and ileum were found in group 2. The highest MT values in the ileum were found in group 4. We found that ZnT2, ZIP2, ZIP4 and MT levels were reduced in the ileum compared to controls following Px, but levels approached control values after MEL administration. By its effects on ZnT2, ZIP2, ZIP4 and MT levels, MEL participates in the absorption of Zn in the rat small intestine.en_US
dc.description.sponsorshipScientific Research Projects Coordinatorship of Selcuk University [15301017]en_US
dc.description.sponsorshipThis study was supported by the Scientific Research Projects Coordinatorship of Selcuk University [SUBAPK; Project no. 15301017].en_US
dc.identifier.doi10.1080/10520295.2021.1885738
dc.identifier.endpage635en_US
dc.identifier.issn1052-0295
dc.identifier.issn1473-7760
dc.identifier.issue8en_US
dc.identifier.pmid33615931en_US
dc.identifier.scopus2-s2.0-85101285253en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage623en_US
dc.identifier.urihttps://doi.org/10.1080/10520295.2021.1885738
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13165
dc.identifier.volume96en_US
dc.identifier.wosWOS:000620567600001en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherTaylor & Francis Ltden_US
dc.relation.ispartofBiotechnic & Histochemistryen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMelatoninen_US
dc.subjectMetallothioneinen_US
dc.subjectPinealectomyen_US
dc.subjectRaten_US
dc.subjectSmall Intestineen_US
dc.subjectZinc Transporter Proteinsen_US
dc.subjectZip2en_US
dc.subjectZip4en_US
dc.subjectZnt2en_US
dc.titleEffect of pinealectomy and melatonin supplementation on metallothionein, ZnT2, ZIP2, ZIP4 and zinc levels in rat small intestineen_US
dc.typeArticleen_US

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