The effects of smoking on vascular endothelial growth factor and inflammation markers: A case-control study

Basit Öğe Kaydı
dc.contributor.authorUgur, Merve Guzeldulger
dc.contributor.authorKutlu, Ruhusen
dc.contributor.authorKilinc, Ibrahim
dc.date.accessioned2024-02-23T14:24:04Z
dc.date.available2024-02-23T14:24:04Z
dc.date.issued2018
dc.departmentNEÜen_US
dc.description.abstractBackground and AimsChronic obstructive pulmonary disease (COPD) is a type of obstructive lung disease characterized by long-term poor airflow. Tobacco smoking is the most common cause of COPD. In this study, we aimed to assess the vascular endothelial growth factor (VEGF) and inflammation markers on smokers and non-smoking individuals. MethodsOur study was a case-control study and 175 individuals who want to give up smoking constituted the case group. As a control group, 175 individuals who never smoked. ResultsThe mean age of 350 participants was 35.8313.11 years. Educational status of the non-smokers was significantly higher than that of the smoking group (P<.001). When smoking and non-smoking groups were compared in terms of VEGF and interleukin-6 (IL-6), it was found that these values were statistically higher in smokers than non-smokers (P<.001). The levels of IL-10 were found to be higher in non-smokers than in smokers (P<.001). Although a moderate positive correlation was found between VEGF and IL-6 levels (r=.486, P<.001), there was a weak negative correlation between VEGF and IL-10 (r=-.210, P<.001). A weak negative correlation was found between IL-6 and IL-10 (r=-.185, P<.001). ConclusionsIn our study, IL-6 inflammatory marker and VEGF levels were found to be high and IL-10 anti-inflammatory marker was discovered to be low in smokers. For this reason, raising awareness in the society about the harms of smoking and encouraging people to give it up have become more challenging to counteract the inflammatory effects of smoking in human body and to prevent many smoking-related diseases.en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Coordination Center [151518013]en_US
dc.description.sponsorshipNecmettin Erbakan University Scientific Research Coordination Center, Grant/Award Number: 151518013en_US
dc.identifier.doi10.1111/crj.12755
dc.identifier.endpage1918en_US
dc.identifier.issn1752-6981
dc.identifier.issn1752-699X
dc.identifier.issue5en_US
dc.identifier.pmid29243879en_US
dc.identifier.scopus2-s2.0-85047878686en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage1912en_US
dc.identifier.urihttps://doi.org/10.1111/crj.12755
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13803
dc.identifier.volume12en_US
dc.identifier.wosWOS:000433595500016en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWileyen_US
dc.relation.ispartofClinical Respiratory Journalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectIl-6en_US
dc.subjectIl-10en_US
dc.subjectInflammationen_US
dc.subjectSmokingen_US
dc.subjectVegfen_US
dc.titleThe effects of smoking on vascular endothelial growth factor and inflammation markers: A case-control studyen_US
dc.typeArticleen_US

Dosyalar

Koleksiyon

WoS İndeksli Yayınlar Koleksiyonu
PubMed İndeksli Yayın Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu