REM parameters in drug-free major depressive disorder: A systematic review and meta-analysis

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dc.contributor.authorArikan, Mehmet K.
dc.contributor.authorUysal, Omer
dc.contributor.authorGica, Sakir
dc.contributor.authorOrhan, Ozden
dc.contributor.authorIlhan, Reyhan
dc.contributor.authorEsmeray, Muhammed T.
dc.contributor.authorBakay, Hasan
dc.date.accessioned2024-02-23T14:16:16Z
dc.date.available2024-02-23T14:16:16Z
dc.date.issued2024
dc.departmentNEÜen_US
dc.description.abstractPrevious studies revealed that rapid eye movement (REM) parameters, such as REM latency (RL) and REM density (RD) could be used as electrophysiological markers of depression. Yet these finding should be re-tested in a comorbid-free and drug-free sample. The present systematic review and meta-analysis was conducted to investigate whether drug-free and comorbid-free patients with unipolar depression differentiate from controls with respect to the RL and RD. The PubMed and Web of Science databases were screened from inception to 23 January 2023 for case-control studies comparing RL and RD of patients with unipolar depression and controls. The primary outcome was the standard mean difference. The data were fitted with a random-effects model. Meta regressions were conducted to investigate patient characteristics and effect size. Publication bias assessment was checked by Egger's Regression and funnel plot asymmetry. Among 43 articles accepted as eligible, 46 RL and 22 RD measurements were included in the meta-analysis. The results indicated shortened RL and increased RD in the patient group than controls. Neither Egger's regression nor funnel plot asymmetry were significant for publication bias. In conclusion, our results tested within drug-free and comorbid-free samples are in line with the literature.en_US
dc.identifier.doi10.1016/j.smrv.2023.101876
dc.identifier.issn1087-0792
dc.identifier.issn1532-2955
dc.identifier.pmid37995418en_US
dc.identifier.scopus2-s2.0-85177855285en_US
dc.identifier.scopusqualityQ1en_US
dc.identifier.urihttps://doi.org/10.1016/j.smrv.2023.101876
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12597
dc.identifier.volume73en_US
dc.identifier.wosWOS:001124527000001en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherW B Saunders Co Ltden_US
dc.relation.ispartofSleep Medicine Reviewsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectMajor Depressive Disorderen_US
dc.subjectBiomarkeren_US
dc.subjectMeta-Analysisen_US
dc.subjectPolysomnographyen_US
dc.subjectRem Densityen_US
dc.subjectRem Latencyen_US
dc.subjectSleep Eegen_US
dc.titleREM parameters in drug-free major depressive disorder: A systematic review and meta-analysisen_US
dc.typeReview Articleen_US

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