The relationship between neutrophil-to-lymphocyte ratio and vascular calcification in end-stage renal disease patients

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dc.contributor.authorTurkmen, Kultigin
dc.contributor.authorOzcicek, Fatih
dc.contributor.authorOzcicek, Adalet
dc.contributor.authorAkbas, Emin Murat
dc.contributor.authorErdur, Fatih Mehmet
dc.contributor.authorTonbul, Halil Zeki
dc.date.accessioned2024-02-23T14:24:15Z
dc.date.available2024-02-23T14:24:15Z
dc.date.issued2014
dc.departmentNEÜen_US
dc.description.abstractChronic inflammation was found to be correlated with coronary (CAC) and thoracic peri-aortic calcification (TAC) in end-stage renal disease (ESRD) patients. Neutrophil-to-lymphocyte ratio (NLR) was introduced as a potential marker to determine inflammation in cardiac and noncardiac disorders. Data regarding NLR and its association with TAC and CAC are lacking. We aimed to determine the relationship between NLR and vascular calcification in ESRD patients. This was a cross-sectional study involving 56 ESRD patients (22 females, 34 males; mean age, 49.9 +/- 14.2 years) receiving peritoneal dialysis or hemodialysis for >= 6 months in the Dialysis Unit of Necmettin Erbakan University. TAC and CAC scores were measured by using an electrocardiogram-gated 64-multidetector computed tomography. NLR was calculated as the ratio of the neutrophils and lymphocytes. There was a statistically significant correlation between NLR, TACS and CACS in ESRD patients (r = 0.43, P = 0.001 and r = 0.30, P = 0.02, respectively). The stepwise linear regression analysis revealed that age, as well as NLR were independent predictors of TACS. However, increased age was the only independent predictor of CACS according to linear regression analysis. Simple calculation of NLR can predict vascular calcification in ESRD patients.en_US
dc.description.sponsorshipScientific Investigation; Project Foundation of Selcuk University Meram School of Medicineen_US
dc.description.sponsorshipThis study was supported by the Scientific Investigation and Project Foundation of Selcuk University Meram School of Medicine. None of the authors have conflict of interest. Authors also do not have any relationships with pharmaceutical companies or other entities such as employment contracts, consultancy, advisory boards, speaker bureaus, membership of Board of Directors, stock ownership.en_US
dc.identifier.doi10.1111/hdi.12065
dc.identifier.endpage53en_US
dc.identifier.issn1492-7535
dc.identifier.issn1542-4758
dc.identifier.issue1en_US
dc.identifier.pmid23819627en_US
dc.identifier.scopus2-s2.0-84891903536en_US
dc.identifier.scopusqualityQ3en_US
dc.identifier.startpage47en_US
dc.identifier.urihttps://doi.org/10.1111/hdi.12065
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13853
dc.identifier.volume18en_US
dc.identifier.wosWOS:000334518900008en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherWiley-Blackwellen_US
dc.relation.ispartofHemodialysis Internationalen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCoronary Artery Calcification Neutrophil-To-Lymphocyte Ratioen_US
dc.subjectThoracic Peri-Aortic Calcificationen_US
dc.subjectEnd-Stage Renal Diseaseen_US
dc.titleThe relationship between neutrophil-to-lymphocyte ratio and vascular calcification in end-stage renal disease patientsen_US
dc.typeArticleen_US

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