Radiotherapy-induced Hypopituitarism in Nasopharyngeal Carcinoma: the Tip of an Iceberg

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dc.contributor.authorIpekci, S. H.
dc.contributor.authorCakir, M.
dc.contributor.authorKiyici, A.
dc.contributor.authorKoc, O.
dc.contributor.authorArtac, M.
dc.date.accessioned2024-02-23T14:16:51Z
dc.date.available2024-02-23T14:16:51Z
dc.date.issued2015
dc.departmentNEÜen_US
dc.description.abstractBackground: Radiation-induced hypopituitarism is an important late complication of cranial radiotherapy in children and adults. The purpose of this cross-sectional study was to evaluate the effects of radiotherapy on pituitary function in adult nasopharyngeal carcinoma patients. Methods: Pituitary function was evaluated in 30 patients after cranial radiotherapy for nasopharyngeal carcinoma. Somatotroph and corticotroph axes were assessed by insulin tolerance test while gonadotroph and thyroid axes were evaluated by basal pituitary and end organ hormone levels at 10-133 months after radiotherapy. Results: At least one hormonal disorder was observed in 28 (93%) patients after radiotherapy. 26 (87%) patients had one or more anterior pituitary hormone deficiencies. The rates of pituitary hormone deficiencies were 77% for growth hormone, followed by adrenocorticotropic hormone (73%), thyroid-stimulating hormone (27%) and gonadotropins (7%). Hyperprolactinemia was present in 13 (43%) patients. Conclusions: Radiation-induced hypopituitarism is more common than expected in patients with nasopharyngeal carcinoma.en_US
dc.identifier.doi10.1055/s-0035-1549963
dc.identifier.endpage418en_US
dc.identifier.issn0947-7349
dc.identifier.issn1439-3646
dc.identifier.issue7en_US
dc.identifier.pmid26011172en_US
dc.identifier.scopus2-s2.0-84946491268en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpage411en_US
dc.identifier.urihttps://doi.org/10.1055/s-0035-1549963
dc.identifier.urihttps://hdl.handle.net/20.500.12452/12834
dc.identifier.volume123en_US
dc.identifier.wosWOS:000357941600006en_US
dc.identifier.wosqualityQ4en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherJohann Ambrosius Barth Verlag Medizinverlage Heidelberg Gmbhen_US
dc.relation.ispartofExperimental And Clinical Endocrinology & Diabetesen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectNasopharyngeal Carcinomaen_US
dc.subjectHypopituitarismen_US
dc.subjectRadiotherapyen_US
dc.subjectRadiation-Induced Hypopituitarismen_US
dc.subjectPituitary Hormone Deficiencyen_US
dc.titleRadiotherapy-induced Hypopituitarism in Nasopharyngeal Carcinoma: the Tip of an Icebergen_US
dc.typeArticleen_US

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