A New Safety Scoring System for the Use of Psychotropic Drugs During Lactation

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dc.contributor.authorUguz, Faruk
dc.date.accessioned2024-02-23T14:21:15Z
dc.date.available2024-02-23T14:21:15Z
dc.date.issued2021
dc.departmentNEÜen_US
dc.description.abstractBackground: Psychotropic drugs are frequently used to treat postpartum women with psychiatric diagnoses, especially psychotic disorder, major depression, and bipolar mood episodes. Pharmacotherapy in breastfeeding mothers is a major challenge. Study Question: This article presents a new safety scoring system for the use of psychotropic drugs during lactation. Study Design: The scoring system is based on the following 6 safety parameters: reported total sample, reported maximum relative infant dose, reported sample size for relative infant dose, infant plasma drug levels, prevalence of reported any adverse effect, and reported serious adverse effects. The total score ranges from 0 to 10. Higher scores represent a higher safety profile. Results: According to this scoring system, sertraline and paroxetine, respectively, had the highest scores representing very good safety profile. Citalopram, olanzapine, and midazolam were assigned to good safety profile. Among drugs evaluated in this article, trifluoperazine, aripiprazole, amisulpride, clozapine, doxepin, zaleplon, and zolpidem are not recommended owing to safety scores <= 3. Conclusions: Most psychotropic drugs examined in this article have moderate or low safety profile.en_US
dc.identifier.doi10.1097/MJT.0000000000000909
dc.identifier.endpageE126en_US
dc.identifier.issn1075-2765
dc.identifier.issn1536-3686
dc.identifier.issue1en_US
dc.identifier.pmid30601177en_US
dc.identifier.scopus2-s2.0-85067671110en_US
dc.identifier.scopusqualityQ2en_US
dc.identifier.startpageE118en_US
dc.identifier.urihttps://doi.org/10.1097/MJT.0000000000000909
dc.identifier.urihttps://hdl.handle.net/20.500.12452/13518
dc.identifier.volume28en_US
dc.identifier.wosWOS:000607300600010en_US
dc.identifier.wosqualityQ3en_US
dc.indekslendigikaynakWeb of Scienceen_US
dc.indekslendigikaynakScopusen_US
dc.indekslendigikaynakPubMeden_US
dc.language.isoenen_US
dc.publisherLippincott Williams & Wilkinsen_US
dc.relation.ispartofAmerican Journal Of Therapeuticsen_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectPyschotropic Drugsen_US
dc.subjectLactationen_US
dc.subjectBreastfeedingen_US
dc.subjectSafetyen_US
dc.titleA New Safety Scoring System for the Use of Psychotropic Drugs During Lactationen_US
dc.typeArticleen_US

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